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Cat No. | Product Name | Synonyms | Targets |
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T76104 | Xanthine oxidase | ||
Xanthine oxidase, a xanthine oxidoreductase enzyme, catalyzes the oxidation of hypoxanthine to xanthine and further oxidizes xanthine to uric acid, generating reactive oxygen species (ROS) [1]. | |||
T10509 | Xanthine oxidase-IN-1 | 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid | Xanthine Oxidase |
Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM. It plays a central role in purine catabolism through the degradation of bioactive nucleotides facilitated by nucleic acid ... | |||
T78984 | Xanthine oxidase-IN-10 | XO8 analog | ROS |
Xanthine oxidase-IN-10 (XO8 analog) is a xanthine oxidase (XO) inhibitor for the study of gout. | |||
T8337 | Nequinate | Xanthine Oxidase , Parasite | |
Nequinate is an anticoccidial agent, preventing coccidiosis . | |||
T1274 | Benzbromarone | Desuric,Normurat,Urinorm | Apoptosis , P450 , Xanthine Oxidase |
Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM. | |||
T60626 | Xanthine oxidase-IN-7 | ||
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active xanthine oxidase(XO) inhibitor (IC50 = 0.36 μM). Xanthine oxidase-IN-7 effectively reduces serum uric acid levels which has the potential in the hyperuricem... | |||
T22304 | Desciclovir | BW A515U,6-Deoxyacyclovir,DCV | Antifection |
Desciclovir (DCV), a prodrug of the antiherpetic agent acyclovir (ACV), is converted in humans to ACV, presumably by xanthine oxidase. | |||
T78985 | Xanthine oxidase-IN-11 | Xanthine Oxidase | |
Xanthine Oxidase-IN-11, an analog of XO8, is an inhibitor of xanthine oxidase (XO) [1]. | |||
T80767 | Xanthine oxidase-IN-12 | Xanthine Oxidase | |
Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), possesses an IC50 value of 91 nM and exhibits antioxidant properties, additionally diminishing intracellular reactive oxygen species (ROS) [1]. | |||
T61092 | Xanthine oxidase-IN-5 | ||
Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic liga... | |||
T72409 | Xanthine oxidase-IN-6 | ||
Xanthine oxidase-IN-6, a potent and orally active mixed-type inhibitor of xanthine oxidase (XOD), demonstrates significant anti-hyperuricemia and renal protective activity with an IC50 value of 1.37 µM. | |||
T60632 | Xanthine oxidase-IN-4 | ||
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent inhibitor of xanthine oxidase(XO) with an IC 50 of 0.039 μM that can be used in the research of hyperuricemia and gout. Xanthine oxidase-IN-4 shows hypo... | |||
T2397 | Topiroxostat | FYX-051 | P450 , ROS , Xanthine Oxidase |
Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout. | |||
T0692 | Allopurinol | Zyloric,Zyloprim,Lopurin | ROS , Xanthine Oxidase |
Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor. | |||
T0773 | Febuxostat | TMX 67,TEI 6720 | ROS , Xanthine Oxidase |
Febuxostat (TEI 6720) is a xanthine oxidase Inhibitor. | |||
T6376 | Allopurinol Sodium | Allopurinol sodium salt,Sodium allopurinol | ROS |
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. | |||
T33676 | Niraxostat | Y 700,Y700,Y-700 | Xanthine Oxidase |
Niraxostat (Y-700) is one of the isocytosine derivatives as xanthine oxidase inhibitors. | |||
T20042 | 8-Azaadenine | NSC 32797,NSC32797,NSC-32797 | Xanthine Oxidase |
8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM. | |||
T9366 | Pyrazoloadenine | 4-Aminopyrazolo[3,4-d]pyrimidine | ROS |
Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase. | |||
T8567 | Amflutizole | Xanthine Oxidase | |
Amflutizole used for the treatment of gout, and is a Xanthine oxidase inhibitor | |||
T20347 | Deoxybenzoin | 2-Phenylacetophenone,Benzyl phenyl ketone,NSC-131456,NSC131456,NSC 131456 | Others |
Deoxybenzoin (2-Phenylacetophenone) is used to target immune sensors and xanthine oxidase. It is used for the treatment of gout. | |||
T60625 | Tigulixostat | ||
Tigulixostat is a novel derivative of (indolyl)heteroarylcarboxylate. Tigulixostat is a non-purine selective xanthine oxidase inhibitor, which lowers the uric acid production[1] | |||
TP1886L1 | NoxA1ds acetate(1435893-78-9 free base) | NADPH-oxidase | |
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col... | |||
T50059 | 6-ethenylquinoline | Others | |
6-ethenylquinoline is a structurally unique aromatic heterocyclic compound that is an important intermediate in the production of other aromatic compounds. It has also been used as a starting material for the synthesis o... | |||
T39012 | O-Desisobutyl-O-n-propyl Febuxostat | ||
O-Desisobutyl-O-n-propyl Febuxostat, an xanthine oxidase inhibitor. | |||
T32905 | LSPN451 | LSPN 451,LSPN-451 | |
LSPN451 is an effective xanthine oxidase inhibitor and may be used to treat hyperuricemia and gout. | |||
T69247 | Febuxostat hemihydrate | ||
Febuxostat hemihydrate is a xanthine oxidase inhibitor used to treat hyperuricemia and chronic gout. | |||
T26058 | Renierol | ||
Renierol is a natural xanthine oxidase inhibitor with hypouricemic effects isolated from marine sponge Halicdona.SP. | |||
T11270 | Febuxostat D9 | Others | |
Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM. | |||
T68437 | Febuxostat 67M-1 | ||
Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. | |||
T69281 | Febuxostat 67M-4 | ||
Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. | |||
T69282 | Febuxostat 67M-2 | ||
Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation. | |||
TP1886 | NoxA1ds | ||
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Atte... | |||
T75949 | NoxA1ds TFA | ||
NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits ... | |||
T73970 | Febuxostat dicarboxylic acid impurity | ||
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73969 | Febuxostat impurity 6 | ||
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73960 | Febuxostat isopropyl isomer | ||
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73967 | Febuxostat impurity 7 | ||
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73966 | Febuxostat sec-butoxy acid | ||
Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73965 | Febuxostat n-butyl isomer | ||
Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73968 | Febuxostat impurity 8 | ||
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] . | |||
T73971 | Febuxostat amide impurity | ||
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] | |||
T61060 | Febuxostat sodium | ||
Febuxostat (TEI 6720) sodium has the potential in gout and hyperuricemia research which is a potent, selective and non-purine inhibitor of xanthine oxidase (XO) with a Ki value of 0.6 nM [1] [2] [3]. | |||
T79177 | URAT1&XO inhibitor 2 | Xanthine Oxidase | |
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in H... | |||
T62350 | XO/COX/LOX-IN-1 | ||
XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be used in the study of inflammatory, cancer and metabolic diseases. | |||
T35976 | 6-Formylpterin | ||
Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photol... | |||
T75501 | Morin 3-O-β-D-glucopyranoside | ||
Morin 3-O-β-D-glucopyranoside, a natural flavonoid, exhibits antifungal, anticancer, and antioxidant properties. This compound also inhibits reverse transcriptase, protein-tyrosine kinase, and xanthine oxidase, while dem... | |||
T79331 | Antioxidant agent-13 | Xanthine Oxidase | |
Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33 µM and 85.69 µM, respectively. Additionally, it inhibits the... | |||
T79175 | URAT1&XO inhibitor 1 | Xanthine Oxidase | |
URAT1&XO Inhibitor 1 (compound 29) serves as a dual inhibitor with IC50 values of approximately 10 μM for URAT1 and 1.01 μM for Xanthine Oxidase. It induces a hypouricemic effect in the potassium oxonate-induced hyperuri... | |||
T36501 | CYPMPO | RR 071 | |
CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first o... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16685 | Purpurogallin | Xanthine Oxidase | |
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 µM). Purpurogallin also has antioxidant and anti-inflammatory effects. | |||
T1694 | Oxypurinol | Oxipurinol | ROS , Xanthine Oxidase , Endogenous Metabolite |
Oxypurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure. | |||
TMA0958 | Forsythoside F | Arenarioside | Xanthine Oxidase |
Forsythoside F (Arenarioside) is a natural product, and GI50 values of 10-16 microM against B16F10 cell. | |||
T2858 | Baicalein | 5,6,7-Trihydroxyflavone | Ferroptosis , Influenza Virus , ROS , Xanthine Oxidase |
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor. | |||
T75504 | Xanthine oxidase-IN-8 | ||
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) serves as an inhibitor of xanthine oxidase, exhibiting an inhibitory concentration (IC50) value of 29.71 μM [1]. | |||
T75505 | Xanthine oxidase-IN-9 | ||
Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1]. | |||
T12564 | Prudomestin | 3,5,7-Trihydroxy-4',8-dimethoxyflavone | Xanthine Oxidase |
Prudomestin (3,5,7-Trihydroxy-4',8-dimethoxyflavone) is a natural product isolated from the heartwood of Prunus domestica, with xanthine oxidase (XO) inhibitory activity with IC50 of 6 µM. | |||
T2971 | Phytic acid | Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),Fytic Acid | Xanthine Oxidase , Endogenous Metabolite |
Phytic acid (Fytic Acid) is a complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent. | |||
T16527 | Phytic acid dodecasodium salt hydrate | myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate | Others , Xanthine Oxidase , Endogenous Metabolite |
Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits th... | |||
T1363 | N-Demethylricinine | 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | ROS |
N-Demethylricinine (4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile) was reported as xanthine oxidase inhibitor. | |||
TN1002 | Blumeatin | ROS | |
Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity. | |||
T3750 | 4-Hydroxyacetophenone | 4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone | HBV , Xanthine Oxidase |
4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor. | |||
T0665 | Xanthine | 2,6-Dihydroxypurine,Isoxanthine | Endogenous Metabolite , Adenosine Receptor |
Xanthine (Isoxanthine) is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most body tissues and fluids in... | |||
TN1962 | Myricetin 3-O-galactoside | Myricetin 3-O-beta-D-galactopyranoside | NOS , Xanthine Oxidase |
Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) can inhibit xanthine oxidase (xanthine oxidase; XO) activity, lipid peroxidation and scavenging free radicals. Myricetin 3-O-galactoside has many effects... | |||
T5S0281 | Tubuloside A | NOS | |
Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflammatory effects.Tubuloside A shows stronge... | |||
T0617 | Nicotinamide N-oxide | Nicotinamide-N-oxide,Nicotinamide 1-oxide,1-oxynicotinamide | c-Myc , Endogenous Metabolite , CXCR , Drug Metabolite |
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of n... | |||
T0626 | Uric Acid | 2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate | Reactive Oxygen Species , Endogenous Metabolite , Phosphorylase |
Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE ... | |||
T1362 | Hypoxanthine | 6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin | Others , Endogenous Metabolite |
Hypoxanthine (Purin-6-ol), also known as purine-6-ol or Hyp. Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the... | |||
T4746 | Purine | 7H-Imidazo(4,5-d)pyrimidine | Others , Endogenous Metabolite |
Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines f... | |||
TN2180 | Sappanchalcone | IL Receptor , BCL , TNF | |
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. | |||
TN5670 | Protosappanin A dimethyl acetal | ||
Protosappanin A dimethyl acetal shows significant xanthine oxidase inhibitory activity in a concentration-dependent manner. | |||
T38777 | Ilexoside O | ||
Ilexoside O, a triterpene saponin derived from Ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (XOD) activity with an IC50 value of 53.05 μM. | |||
TN3208 | 7,3',4'-Trihydroxy-3-benzyl-2H-chromene | ROS | |
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor. | |||
T75546 | Ellagic acid 4-O-β-D-xylopyranoside | ||
Ellagic acid 4-O-β-D-xylopyranoside, an ellagitannin found naturally, exhibits antimicrobial properties and acts as an inhibitor of xanthine oxidase, displaying an IC50 value of 2.1 μg/mL [1]. | |||
TN1503 | Cistanoside F | NADPH-oxidase | |
Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide ani... | |||
TN4080 | Fraxamoside | Xanthine Oxidase | |
Fraxamoside is a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. It shows significant free radical scavenging effect against DPPH(EC50=62.6 uM). | |||
TN3473 | Axillarin | ||
Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress. | |||
T82649 | Cyanidin | ||
Cyanidin, an antioxidant, exhibits protective effects against DNA cleavage, demonstrates free radical scavenging activity, and significantly inhibits xanthine oxidase (XO) activity [1]. | |||
TN4433 | Licoarylcoumarin | cAMP , HIV Protease , Antifection | |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effe... | |||
T72594 | Broussochalcone A | ||
Broussochalcone A, an antioxidant and Xanthine Oxidase inhibitor (IC 50 =2.21 μM), exhibits free radical scavenging activity. It prevents iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02464 | Catalase/CAT Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin heme groups that allow the enz... |