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Cell Cycle/Checkpoint c-Myc

c-Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
Cat No. product name
T0617 Nicotinamide-N-oxide Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enz...
T2091 CPI-0610 CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
T3048 10058-F4 10058-F4 is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; i...
T3686 10074-G5 10074-G5 is an inhibitor of c-Myc-Max dimerization.
T4367 Mycro-3 Mycro 3 is potent and selective for c-Myc in whole cell assays.
T4252 ML327 ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
TN2177 Sanggenol L Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopt...
TN1103 Diphyllin Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
TN1354 Aaptamine Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
T12133 MYCi975 MYCi975 is an orally active inhibitor of MYC.
T10352 APTO-253 APTO-253 inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates ...
T10702 CBP/EP300-IN-2 CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
T15665 KJ Pyr 9 KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).
T11783 KSI-3716 KSI-3716 is an inhibitor of c-Myc.
T16839 sAJM589 sAJM589 is a Myc inhibitor(IC50: 1.8 μM).
T12132 MYCi361 MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
T3851 Vicenin -2 Vicenin -2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the singl...
TN3708 Coronarin D Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
TN4581 Moracin D Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
TN4582 Moracin T Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...
Nicotinamide-N-oxide
T0617CAS 1986-81-8
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enz...
CPI-0610
T2091CAS 1380087-89-7
CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
10058-F4
T3048CAS 403811-55-2
10058-F4 is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; i...
10074-G5
T3686CAS 413611-93-5
10074-G5 is an inhibitor of c-Myc-Max dimerization.
Mycro-3
T4367CAS 944547-46-0
Mycro 3 is potent and selective for c-Myc in whole cell assays.
ML327
T4252CAS 1883510-31-3
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
Sanggenol L
TN2177CAS 329319-20-2
Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopt...
Diphyllin
TN1103CAS 22055-22-7
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
Aaptamine
TN1354CAS 85547-22-4
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
MYCi975
T12133CAS 2289691-01-4
MYCi975 is an orally active inhibitor of MYC.
APTO-253
T10352CAS 916151-99-0
APTO-253 inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates ...
CBP/EP300-IN-2
T10702CAS 2158265-96-2
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
KJ Pyr 9
T15665CAS 581073-80-5
KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).
KSI-3716
T11783CAS 1151813-61-4
KSI-3716 is an inhibitor of c-Myc.
sAJM589
T16839CAS 2089-82-9
sAJM589 is a Myc inhibitor(IC50: 1.8 μM).
MYCi361
T12132CAS 2289690-31-7
MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
Vicenin -2
T3851CAS 23666-13-9
Vicenin -2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the singl...
Coronarin D
TN3708CAS 119188-37-3
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
Moracin D
TN4581CAS 69120-07-6
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
Moracin T
TN4582CAS 1146113-27-0
Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...