c-Met/HGFR

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing.

Cat. No.	Product name	CAS No.	Purity
T5S1331	Herbacetin	527-95-7	98.54%
T5S1331	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 ...
T2516	Amuvatinib	850879-09-3	98.48%
T2516	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T6378	AMG-458	913376-83-7	98.39%
T6378	AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
T5467	SAR125844	1116743-46-4	98.39%
T5467	SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)
T6121	Tepotinib	1100598-32-0	98.35%
T6121	Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.
T4332	C-Kit-IN-1	1225278-16-9	98.16%
T4332	c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).
T1918	NVP-TAE 226	761437-28-9	98.07%
T1918	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
TQ0210	Savolitinib	1313725-88-0	98.03%
TQ0210	Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).
T7376	Dihexa	1401708-83-5	98%
T7376	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the pept...
T2282	RPI-1	269730-03-2	98%
T2282	RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
T6907	NPS-1034	1221713-92-3	97.86%
T6907	NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
T3274	S49076	1265965-22-7	97.4%
T3274	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
TQ0219	MK-8033	1001917-37-8	97.16%
TQ0219	MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).
T6095	JNJ-38877605	943540-75-8	97.15%
T6095	JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
T5164	Cabozantinib hydrochloride	1817759-42-4	97.09%
T5164	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM...
T39507L	Fosgonimeton acetate		97.05%
T39507L	Fosgonimeton acetate is an agonist of hepatocyte growth factor (HGF).
T67859	C-Met inhibitor D9	299405-67-7	97%
T67859	C-Met inhibitor D9 is a c-Met kinase inhibitor.
T5677	SAR125884 hydrochlorid (1116743-46-4(free base))	T5677	95%
T5677	SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM).
T2208	Bacitracin Zinc	1405-89-6	63.98%
T2208	Bacitracin Zinc is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, interference for inhibition of cleavage of Tyr from M...
T5414	Glumetinib	1642581-63-2	100%
T5414	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).