iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat. No.	Product name	CAS No.	Purity
T4096	Quinolinic acid	89-00-9	99.93%
T4096	Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T5385	Radiprodil	496054-87-6	99.9%
T5385	Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with...
T6352	(-)-Dizocilpine maleate	121917-57-5	99.89%
T6352	(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T16964	SYM2206	173952-44-8	99.88%
T16964	SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated ...
T7720	CGP 37849	127910-31-0	99.87%
T7720	CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents an...
T3026	(-)-Huperzine A	102518-79-6	99.87%
T3026	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (A...
T3379	Decanoic Acid	334-48-5	99.87%
T3379	Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.
TQ0233	Traxoprodil	134234-12-1	99.86%
TQ0233	Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T13456	(S)-Willardiine	21416-43-3	99.85%
T13456	(S)-Willardiine (L-willardiine) is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM).
T27951	LY392098	211311-39-6	99.85%
T27951	LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.
T1589	D-Cycloserine	68-41-7	99.83%
T1589	D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with oth...
T6608	NMDA	6384-92-5	99.81%
T6608	N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate re...
T0333	Aniracetam	72432-10-1	99.8%
T0333	Aniracetam (Ro 13-5057)(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T1751	Eliprodil	119431-25-3	99.77%
T1751	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 u...
T17293	ZL006	1181226-02-7	99.75%
T17293	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T4885	(-)-Aspartic acid	1783-96-6	99.74%
T4885	(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist...
T0426	Piracetam	7491-74-9	99.72%
T0426	Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T2A2497	L-Glutamic acid	56-86-0	99.7%
T2A2497	L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T1186	Ifenprodil Tartrate	23210-58-4	99.7%
T1186	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T10781	CGP 78608 hydrochloride	1135278-54-4	99.68%
T10781	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant ...