iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat. No.	Product name	CAS No.	Purity
T3407	Rapastinel	117928-94-6	99.67%
T3407	Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T2362	QNZ46	1237744-13-6	99.64%
T2362	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T13480	(S)-(-)-5-Fluorowillardiine	140187-23-1	99.60%
T13480	(S)-(-)-5-Fluorowillardiine ((S)-5-Fluorowillardiine) is an AMPA receptor-specific agonist
T3407L	Rapastinel acetate	491872-39-0	99.6%
T3407L	Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
T16963	SYM 2081	31137-74-3	99.59%
T16963	SYM 2081 is a specific kainate receptor agonist with an IC50 value of 35 nM for [3H]-kainate binding. SYM 2081 depolarizes the muscle and reduces the EPSP amplit...
T9177	BPAM344	1204572-55-3	99.57%
T9177	BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
T1308	Orphenadrine hydrochloride	341-69-5	99.54%
T1308	Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T2O2728	Glycine	56-40-6	99.54%
T2O2728	glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also ...
T17179	Tulrampator	1038984-31-4	99.51%
T17179	Tulrampator (S-47445) is an orally bioavailable positive AMPAR with antidepressant effects.
T3377	L-Phenylalanine	63-91-2	99.49%
T3377	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
T4113	NBQX	118876-58-7	99.42%
T4113	NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T34609	Selurampanel	912574-69-7	99.41%
T34609	Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in ...
T5819	Rapastinel Trifluoroacetate	1435786-04-1	99.37%
T5819	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
T7304	DNQX	2379-57-9	99.32%
T7304	DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T0324	Isoxsuprine hydrochloride	579-56-6	99.31%
T0324	Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
T8920	Sepimostat	103926-64-3	99.3%
T8920	Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dim...
T1884	CX516	154235-83-3	99.29%
T1884	CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild c...
TQ0027	Transcrocetinate disodium	591230-99-8	99.22%
TQ0027	Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T4S0171	Transcrocetin	27876-94-4	99.2%
T4S0171	Transcrocetin (8,8'-Diapocarotenedioic Acid) is a singlet oxygen quencher.
T61518	TAK-653	1358751-06-0	99.18%
T61518	TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while m...