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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1897 MDL-29951 130798-51-5 99.07%
MDL-29951
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T22798 Gavestinel 153436-38-5 99.04%
Gavestinel
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA...
T1401 Meclofenoxate hydrochloride 3685-84-5 99.04%
Meclofenoxate hydrochloride
Meclofenoxate hydrochloride (Lucidril) is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cog...
T0556 6-Methoxy-2-naphthoic acid 2471-70-7 99.03%
6-Methoxy-2-naphthoic acid
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
T8394 D-Serine 312-84-5 99%
D-Serine
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T6504 Flupirtine maleate 75507-68-5 98.99%
Flupirtine maleate
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
T7870 TCN 201 852918-02-6 98.97%
TCN 201
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T2S2264 Linalool 78-70-6 98.95%
Linalool
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
T10307 AMPA receptor modulator-1 2036074-41-4 98.82%
AMPA receptor modulator-1
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
T31208 Dasolampanel 503294-13-1 98.81%
Dasolampanel
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, includi...
T7599 Sunifiram 314728-85-3 98.81%
Sunifiram
Sunifiram (DM-235) is a potent nootropic agent.
T62042 BDZ-g 732278-52-3 98.77%
BDZ-g
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of...
T72662 NMDAR/TRPM4-IN-2 2243506-33-2 98.77%
NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T21584 CP 465022 199655-36-2 98.75%
CP 465022
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kain...
T16524 Philanthotoxin 74 dihydrochloride 1227301-51-0 98.6%
Philanthotoxin 74 dihydrochloride
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
T8458 CNQX disodium 479347-85-8 98.46%
CNQX disodium
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
T9133 Caroverine hydrochloride 55750-05-5 98.37%
Caroverine hydrochloride
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and c...
T13248 UK-240455 178908-09-3 98.34%
UK-240455
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T61813 AMPA receptor antagonist-3 923272-18-8 98.24%
AMPA receptor antagonist-3
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
T61068 AMPA receptor antagonist-2 732277-05-3 98.21%
AMPA receptor antagonist-2
AMPA receptor antagonist-2 is an AMPA receptor antagonist.
MDL-29951
T1897
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
Gavestinel
T22798
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA...
Meclofenoxate hydrochloride
T1401
Meclofenoxate hydrochloride (Lucidril) is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cog...
6-Methoxy-2-naphthoic acid
T0556
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
D-Serine
T8394
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
Flupirtine maleate
T6504
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
TCN 201
T7870
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
Linalool
T2S2264
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
AMPA receptor modulator-1
T10307
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Dasolampanel
T31208
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, includi...
Sunifiram
T7599
Sunifiram (DM-235) is a potent nootropic agent.
BDZ-g
T62042
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of...
NMDAR/TRPM4-IN-2
T72662
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
CP 465022
T21584
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kain...
Philanthotoxin 74 dihydrochloride
T16524
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
CNQX disodium
T8458
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
Caroverine hydrochloride
T9133
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and c...
UK-240455
T13248
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
AMPA receptor antagonist-3
T61813
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
AMPA receptor antagonist-2
T61068
AMPA receptor antagonist-2 is an AMPA receptor antagonist.
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TargetMol