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Autophagy lysosomal autophagy

lysosomal autophagy

Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore. The edges of the phagophore expand while becoming spherical until they seal, enclosing the engulfed pieces of cytoplasm with whatever might lie inside, and giving rise to a double-membrane vesicle. Farquhar observed these closed vesicles, which are known as autophagosomes. Autophagosomes take up damaged molecules or organelles and carry this cargo to the lysosomes. When de Duve observed autophagosomes, he realized that cells could degrade their own components and named the process "autophagy"
Cat No. product name
T1885 Siramesine hydrochloride Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anti...
T3437 Lys05 Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more pot...
T1537 RapamycinHOT Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
Siramesine hydrochloride
T1885CAS 224177-60-0
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anti...
Lys05
T3437CAS 1391426-24-6
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more pot...
Rapamycin HOT
T1537CAS 53123-88-9
Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).