T67703 |
MTOR inhibitor 9b
|
1144075-34-2
|
99.53%
|
|
mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inh...
|
T1916 |
Apitolisib
|
1032754-93-0
|
99.52%
|
|
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study...
|
T3153 |
Serabelisib
|
1268454-23-4
|
99.5%
|
|
Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).
|
T1784 |
Everolimus
|
159351-69-6
|
99.48%
|
|
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
|
T6100 |
Torin 2
|
1223001-51-1
|
99.47%
|
|
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
|
T9831 |
MKC-1
|
125313-92-0
|
99.46%
|
|
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its meta...
|
T6845 |
GNE-317
|
1394076-92-6
|
99.42%
|
|
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
|
T3351 |
Onatasertib
|
1228013-30-6
|
99.41%
|
|
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
|
T6030 |
XL388
|
1251156-08-7
|
99.39%
|
|
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
|
T6045 |
Torin 1
|
1222998-36-8
|
99.38%
|
|
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
|
T11928 |
M2698
|
1379545-95-5
|
99.36%
|
|
M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
|
T7014 |
Voxtalisib
|
934493-76-2
|
99.36%
|
|
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
|
T3895 |
Polyphyllin I
|
50773-41-6
|
99.36%
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|
T1838 |
Sapanisertib
|
1224844-38-5
|
99.34%
|
|
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antine...
|
T12589 |
PI3Kα/mTOR-IN-1
|
1013098-90-2
|
99.3%
|
|
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTO...
|
T6143 |
PI-103
|
371935-74-9
|
99.3%
|
|
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
|
T2717 |
Salidroside
|
10338-51-9
|
99.25%
|
|
Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor.
|
T9310 |
MTOR inhibitor 13
|
1144075-44-4
|
99.24%
|
|
mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively.
|
T2414 |
Torkinib
|
1092351-67-1
|
99.23%
|
|
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
|
T8884 |
HSMG-1 inhibitor 11j
|
1402452-15-6
|
99.22%
|
|
hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibit...
|