T67704 |
MTOR inhibitor 9e
|
1144075-40-0
|
98.80%
|
|
mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.
|
T6072 |
BGT226 maleate
|
1245537-68-1
|
98.78%
|
|
BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
|
T67706 |
MTOR inhibitor 9c
|
1144075-36-4
|
98.73%
|
|
mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.
|
T6251 |
PF-04691502
|
1013101-36-4
|
98.63%
|
|
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
|
T14886 |
Cbz-B3A
|
1884710-81-9
|
98.63%
|
|
Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
|
T4488 |
GSK-25
|
874119-56-9
|
98.59%
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
|
T6303L |
CCT128930 hydrochloride
|
2453324-32-6
|
98.55%
|
|
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest...
|
T3514 |
CZ415
|
1429639-50-8
|
98.44%
|
|
CZ415 is a potent and highly selective mTOR inhibitor.
|
T5S0506 |
Rotundic acid
|
20137-37-5
|
98.43%
|
|
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (N...
|
T6103 |
VS-5584
|
1246560-33-7
|
98.41%
|
|
VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
|
T67701 |
MTOR inhibitor 9f
|
1144075-42-2
|
98.39%
|
|
mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.
|
T2475 |
KU-0063794
|
938440-64-3
|
98.35%
|
|
KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.
|
T36200 |
AZD 3147
|
1101810-02-9
|
98.34%
|
|
AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI...
|
T6731 |
WYE-354
|
1062169-56-5
|
98.31%
|
|
WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selec...
|
T36316 |
MTOR inhibitor-8
|
2489196-70-3
|
98.11%
|
|
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, whic...
|
T5472 |
PQR620
|
1927857-56-4
|
98.11%
|
|
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
|
T9950 |
ElteN378
|
1421366-99-5
|
98.09%
|
|
ElteN378 is a highly potent synthetic inhibitor of FKBP12 with Ki of 0.5 nM, a low atomic weight ligand with affinity comparable to that of the macrolide Rapamyc...
|
T1537 |
Rapamycin
|
53123-88-9
|
98.09%
|
|
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity...
|
T3986 |
SF2523
|
1174428-47-7
|
98.06%
|
|
SF2523 is a highly selective and potent inhibitor.
|
T16156 |
MT 63-78
|
1179347-65-9
|
98.03%
|
|
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathway...
|