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mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9314 CC214-1 1021920-32-0 97.87%
CC214-1
CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for ex...
T3986 SF2523 1174428-47-7 97.78%
SF2523
SF2523 is a highly selective and potent inhibitor.
T2974 Cyclovirobuxine D 860-79-7 97.78%
Cyclovirobuxine D
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
T1908 MHY1485 326914-06-1 97.74%
MHY1485
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3I...
T2145 Temsirolimus 162635-04-3 97.69%
Temsirolimus
Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.
T6354 (+)-Usnic acid 7562-61-0 97.61%
(+)-Usnic acid
(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
T1859 AZD-8055 1009298-09-2 97.45%
AZD-8055
AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
T4423 LY 303511 hydrochloride 2070014-90-1 97.44%
LY 303511 hydrochloride
LY 303511 hydrochloride is a potent mTOR inhibitor
TN1405 Arnicolide D 34532-68-8 96.66%
Arnicolide D
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T14033 3BDO 890405-51-3 96.00%
3BDO
3BDO is an activator of mTOR. It can also inhibit autophagy..
T6072L BGT226 915020-55-2 95.74%
BGT226
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
T3541 CC-115 1228013-15-7 86.79%
CC-115
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T4199 Desmethyl-VS-5584 1246535-95-4 100%
Desmethyl-VS-5584
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
T63399L MTOR/HDAC-IN-1 HCl 100%
mTOR/HDAC-IN-1 HCl
mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for...
T3656 PKI-402 1173204-81-3 100%
PKI-402
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
T5338 MTOR inhibitor-1 468747-17-3 100%
mTOR inhibitor-1
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
T3O2749 L-Leucine 61-90-5 100%
L-Leucine
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functi...
T3S0209 Vincristine 57-22-7 100%
Vincristine
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
T7343 PF-04979064 1220699-06-8
PF-04979064
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
T12270 NV-5138 2095886-80-7
NV-5138
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.
CC214-1
T9314
CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for ex...
SF2523
T3986
SF2523 is a highly selective and potent inhibitor.
Cyclovirobuxine D
T2974
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
MHY1485
T1908
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3I...
Temsirolimus
T2145
Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.
(+)-Usnic acid
T6354
(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
AZD-8055
T1859
AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
LY 303511 hydrochloride
T4423
LY 303511 hydrochloride is a potent mTOR inhibitor
Arnicolide D
TN1405
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
3BDO
T14033
3BDO is an activator of mTOR. It can also inhibit autophagy..
BGT226
T6072L
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
CC-115
T3541
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
Desmethyl-VS-5584
T4199
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
mTOR/HDAC-IN-1 HCl
T63399L
mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for...
PKI-402
T3656
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
mTOR inhibitor-1
T5338
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
L-Leucine
T3O2749
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functi...
Vincristine
T3S0209
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
PF-04979064
T7343
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
NV-5138
T12270
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.
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TargetMol