T9314 |
CC214-1
|
1021920-32-0
|
97.87%
|
|
CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for ex...
|
T3986 |
SF2523
|
1174428-47-7
|
97.78%
|
|
SF2523 is a highly selective and potent inhibitor.
|
T2974 |
Cyclovirobuxine D
|
860-79-7
|
97.78%
|
|
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
|
T1908 |
MHY1485
|
326914-06-1
|
97.74%
|
|
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3I...
|
T2145 |
Temsirolimus
|
162635-04-3
|
97.69%
|
|
Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.
|
T6354 |
(+)-Usnic acid
|
7562-61-0
|
97.61%
|
|
(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
|
T1859 |
AZD-8055
|
1009298-09-2
|
97.45%
|
|
AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
|
T4423 |
LY 303511 hydrochloride
|
2070014-90-1
|
97.44%
|
|
LY 303511 hydrochloride is a potent mTOR inhibitor
|
TN1405 |
Arnicolide D
|
34532-68-8
|
96.66%
|
|
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
|
T14033 |
3BDO
|
890405-51-3
|
96.00%
|
|
3BDO is an activator of mTOR. It can also inhibit autophagy..
|
T6072L |
BGT226
|
915020-55-2
|
95.74%
|
|
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
|
T3541 |
CC-115
|
1228013-15-7
|
86.79%
|
|
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
|
T4199 |
Desmethyl-VS-5584
|
1246535-95-4
|
100%
|
|
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
|
T63399L |
MTOR/HDAC-IN-1 HCl
|
|
100%
|
|
mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for...
|
T3656 |
PKI-402
|
1173204-81-3
|
100%
|
|
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
|
T5338 |
MTOR inhibitor-1
|
468747-17-3
|
100%
|
|
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
|
T3O2749 |
L-Leucine
|
61-90-5
|
100%
|
|
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functi...
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T7343 |
PF-04979064
|
1220699-06-8
|
|
|
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
|
T12270 |
NV-5138
|
2095886-80-7
|
|
|
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.
|