TN1211 |
2-Hydroxy-3-methylanthraquinone
|
17241-40-6
|
98%
|
|
2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
|
T16477 |
PF-03715455
|
1056164-52-3
|
98%
|
|
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715...
|
T10298L |
AMG-548
|
864249-60-5
|
98%
|
|
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38...
|
TN3711 |
Corylifol C
|
775351-91-2
|
98%
|
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
|
T10298L2 |
AMG-548 dihydrochloride (864249-60-5 free base)
|
T10298L2
|
98%
|
|
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective...
|
TL0014 |
Pinusolide
|
31685-80-0
|
98%
|
|
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
|
TN3719 |
Cristacarpin
|
74515-47-2
|
98%
|
|
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
|
TN5050 |
Sprengerinin C
|
88861-91-0
|
98%
|
|
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
|
T11327 |
FR 167653
|
158876-66-5
|
98%
|
|
FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. ...
|
TN3839 |
Desoxo-narchinol A
|
53859-06-6
|
98%
|
|
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
|
TN2075 |
Pimaric acid
|
127-27-5
|
98%
|
|
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human ...
|
TN4490 |
Manassantin B
|
88497-88-5
|
98%
|
|
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
|
TN1882 |
Lucidenic acid D
|
98665-16-8
|
98%
|
|
Lucidenic acid D2 is a nartural product from G. lucidum AF.
|
T3229 |
Cytochalasin D
|
22144-77-0
|
98%
|
|
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
|
TN2039 |
Panaxydol
|
72800-72-7
|
98%
|
|
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MA...
|
T12871L |
Talmapimod hydrochloride
|
309915-12-6
|
98%
|
|
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fol...
|
TN3931 |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
|
57719-81-0
|
98%
|
|
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
|
TN4162 |
Goshonoside F5
|
90851-28-8
|
98%
|
|
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
|
T36067 |
Bongkrekic acid
|
11076-19-0
|
98%
|
|
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).B...
|
TMA0291 |
Dehydroglyasperin D
|
517885-72-2
|
98%
|
|
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
|