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p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN4307 Isolimonexic acid 73904-93-5 98%
Isolimonexic acid
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
TN1379 Alphitolic acid 19533-92-7 98%
Alphitolic acid
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN3252 7alpha,15-Dihydroxydehydroabietic acid 155205-64-4 98%
7alpha,15-Dihydroxydehydroabietic acid
7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
T12472 Pifithrin-α, p-Nitro, Cyclic 60477-38-5 99.97%
Pifithrin-α, p-Nitro, Cyclic
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
T5S0331 Isoliquiritin 5041-81-6 99.88%
Isoliquiritin
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin in...
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 569-83-5 99.79%
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
T37562 C16 Ceramide 24696-26-2 99.7%
C16 Ceramide
C16 Ceramide (Palmitoyl Ceramide) is a natural small molecule activating p53 through the direct and selective binding.
T6909 NSC348884 81624-55-7 99.65%
NSC348884
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
T67698 P53-Mdm2 inhibitor 4 350678-63-6 99.63%
p53-Mdm2 inhibitor 4
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
T3637 Pifithrin-β hydrobromide 511296-88-1 99.62%
Pifithrin-β hydrobromide
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuron...
T28078 MMRi64 430458-66-5 99.61%
MMRi64
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel...
TP1427L ReACp53 acetate TP1427L 99.55%
ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.
T21648 CP-31398 dihydrochloride 1217195-61-3 99.53%
CP-31398 dihydrochloride
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-t...
T4325 COTI-2 1039455-84-9 99.49%
COTI-2
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
T2970 Rotenone 83-79-4 99.48%
Rotenone
Rotenone (Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papil...
T1919 Tenovin-1 380315-80-0 99.44%
Tenovin-1
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T6910 NSC59984 803647-40-7 99.39%
NSC59984
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
T22980 MIRA-1 72835-26-8 99.38%
MIRA-1
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with...
T6210 Pifithrin-μ 64984-31-2 99.33%
Pifithrin-μ
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
Isolimonexic acid
TN4307
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
Alphitolic acid
TN1379
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
7alpha,15-Dihydroxydehydroabietic acid
TN3252
7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
Pifithrin-α, p-Nitro, Cyclic
T12472
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
Isoliquiritin
T5S0331
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin in...
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
C16 Ceramide
T37562
C16 Ceramide (Palmitoyl Ceramide) is a natural small molecule activating p53 through the direct and selective binding.
NSC348884
T6909
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
p53-Mdm2 inhibitor 4
T67698
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
Pifithrin-β hydrobromide
T3637
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuron...
MMRi64
T28078
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel...
ReACp53 acetate
TP1427L
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.
CP-31398 dihydrochloride
T21648
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-t...
COTI-2
T4325
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
Rotenone
T2970
Rotenone (Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papil...
Tenovin-1
T1919
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
NSC59984
T6910
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
MIRA-1
T22980
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with...
Pifithrin-μ
T6210
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
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TargetMol