TN4307 |
Isolimonexic acid
|
73904-93-5
|
98%
|
|
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
|
TN1379 |
Alphitolic acid
|
19533-92-7
|
98%
|
|
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
TN3252 |
7alpha,15-Dihydroxydehydroabietic acid
|
155205-64-4
|
98%
|
|
7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
|
T12472 |
Pifithrin-α, p-Nitro, Cyclic
|
60477-38-5
|
99.97%
|
|
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
|
T5S0331 |
Isoliquiritin
|
5041-81-6
|
99.88%
|
|
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin in...
|
TN5263 |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
|
569-83-5
|
99.79%
|
|
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
|
T37562 |
C16 Ceramide
|
24696-26-2
|
99.7%
|
|
C16 Ceramide (Palmitoyl Ceramide) is a natural small molecule activating p53 through the direct and selective binding.
|
T6909 |
NSC348884
|
81624-55-7
|
99.65%
|
|
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
|
T67698 |
P53-Mdm2 inhibitor 4
|
350678-63-6
|
99.63%
|
|
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
|
T3637 |
Pifithrin-β hydrobromide
|
511296-88-1
|
99.62%
|
|
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuron...
|
T28078 |
MMRi64
|
430458-66-5
|
99.61%
|
|
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel...
|
TP1427L |
ReACp53 acetate
|
TP1427L
|
99.55%
|
|
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.
|
T21648 |
CP-31398 dihydrochloride
|
1217195-61-3
|
99.53%
|
|
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-t...
|
T4325 |
COTI-2
|
1039455-84-9
|
99.49%
|
|
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
|
T2970 |
Rotenone
|
83-79-4
|
99.48%
|
|
Rotenone (Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papil...
|
T1919 |
Tenovin-1
|
380315-80-0
|
99.44%
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
|
T6910 |
NSC59984
|
803647-40-7
|
99.39%
|
|
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
|
T22980 |
MIRA-1
|
72835-26-8
|
99.38%
|
|
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with...
|
T6210 |
Pifithrin-μ
|
64984-31-2
|
99.33%
|
|
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
|