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KD-3010
😃Good
Catalog No. T11747Cas No. 934760-92-6
KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.
KD-3010
😃Good
Purity: 99.61%
Catalog No. T11747Cas No. 934760-92-6
KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Purity:99.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury. |
| In vivo | To investigate the potential benefits of PPARδ agonists in experimental liver fibrosis, mice are orally treated with a PPARδ agonist, KD-3010, or the well-validated PPARδ agonist GW501516. In liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL), KD-3010, but not GW501516, demonstrates hepatoprotective and antifibrotic effects. The induction of liver injury is achieved through repeated injections of CCl4, and mice are orally administered vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 on a daily basis. Control mice injected with oil do not exhibit liver damage. Liver injury, characterized by hepatocyte death and inflammation, is observed in the group treated with vehicle or GW501516 and injected with CCl4 based on H&E-stained liver sections, but this injury is markedly reduced in the KD-3010-treated group[1]. |
| Molecular Weight | 670.72 |
| Formula | C30H33F3N2O8S2 |
| Cas No. | 934760-92-6 |
| Smiles | S(=O)(=O)(O)C1=CC=C(C)C=C1.S(=O)(=O)(C1=C2C(C[C@H](C(O)=O)C2)=CC=C1)N3[C@H](C)CN(C[C@@H]3C)C4=CC=C(OC(F)(F)F)C=C4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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