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L-655708
🥰Excellent
Catalog No. TQ0151Cas No. 130477-52-0
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
L-655708
🥰Excellent
Purity: 98.41%
Catalog No. TQ0151Cas No. 130477-52-0
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $77 | In Stock | |
| 10 mg | $127 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $517 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $85 | In Stock |
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Purity:98.41%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM. |
| Targets&IC50 | GABAA:0.45 nM (Ki) |
| In vitro | L655708, a potent and selective inverse agonist, targets the benzodiazepine site of GABAA receptors that contain the α5 subunit (Ki = 0.45 nM). It exhibits remarkable selectivity, with a 50-100-fold preference for GABAA receptors containing α1, α2, α3, or α6 subunits when combined with β3 and γ2. In a mouse hippocampal slice model, L655708 enhances long-term potentiation (LTP) and improves spatial learning. Notably, it does so without displaying proconvulsant activity. |
| In vivo | At an intraperitoneal administration of 0.7 mg/kg, L-655708 achieves 60-70% occupancy of α5 GABAA receptors, with minimal binding to GABAA receptors containing α1, α2, and α3 subunits. Furthermore, there are no significant off-target behavioral effects, such as sedation and motor impairment. |
| Molecular Weight | 341.36 |
| Formula | C18H19N3O4 |
| Cas No. | 130477-52-0 |
| Smiles | [H][C@@]12CCCN1C(=O)c1cc(OC)ccc1-n1cnc(C(=O)OCC)c21 |
| Relative Density. | 1.42 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (14.65 mM), Sonication is recommended. H2O: Insoluble | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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