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OSIP-486823
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Catalog No. T13807Cas No. 200803-37-8
Alias CP248
OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
OSIP-486823
😃Good
Purity: 98.59%
Catalog No. T13807Alias CP248Cas No. 200803-37-8
OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $566 | 6-8 weeks | |
| 5 mg | $1,180 | 6-8 weeks | |
| 10 mg | $1,620 | 6-8 weeks | |
| 25 mg | $2,390 | 6-8 weeks | |
| 50 mg | $3,250 | 6-8 weeks |
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Purity:98.59%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules. |
| Targets&IC50 | SW480:0.1 μM |
| In vitro | In SW480 human colon cancer cells, OSIP-486823 inhibits growth and induces apoptosis with an IC50 of 0.1 μM. OSIP-486823, a member of a new class of drugs known as selective apoptotic antineoplastic drugs targeting cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE), causes depolymerization of microtubules in interphase cells, inhibits spindle formation in mitotic cells, and induces multinucleated cells. Furthermore, OSIP-486823 disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells [1]. |
| Alias | CP248 |
| Molecular Weight | 473.54 |
| Formula | C29H28FNO4 |
| Cas No. | 200803-37-8 |
| Smiles | COc1cc(\C=C2\C(C)=C(CC(=O)NCc3ccccc3)c3cc(F)ccc23)cc(OC)c1OC |
| Relative Density. | 1.206 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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