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(±)14(15)-EET

Catalog No. T35463 CAS 197508-62-6

Synonyms: (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-EET

(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]

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(±)14(15)-EET, CAS 197508-62-6

Pack Size	Availability	Price/USD	Quantity
100 μg	35 days	$ 535.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	(±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-EET
Molecular Weight	320.473
Formula	C20H32O3
CAS No.	197508-62-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: >50 mg/mL (per Rao Maddipati)

DMF: >50 mg/mL (per Rao Maddipati)

DMSO: >50 mg/mL (per Rao Maddipati)

References and Literature

1. Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem. Biophys. Res. Commun. 104(3), 916-922 (1982). 2. Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J. Biol. Chem. 257(7), 3771-3781 (1982). 3. Jiang, J.-X., Zhang, S.-J., Xiong, Y.-K., et al. EETs attenuate ox-LDL-induced LTB4 production and activity by inhibiting p38 MAPK phosphorylation and 5-LO/BLT1 receptor expression in rat pulmonary arterial endothelial cells. PLoS One 10(6), e0128278 (2015). 4. Oltman, C.L., Weintraub, N.L., VanRollins, M., et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998). 5. Nithipatikom, K., Moore, J.M., Isbell, M.A., et al. Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 291(2), H537-H542 (2006).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(±)14(15)-EET 197508-62-6 (±)14(15) EET 14,15-EpETrE 14(15)-EET (±)14(15)EET (±)14,15-EET 14,15-EET (±)14,15-EpETrE inhibitor inhibit

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