P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat No.	product name
T0179	Ticagrelor	Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The...
T0595	Naringin	Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibiti...
T0660	Beta-Tetralone	Beta-Tetralone is a ketone derivative of tetralin.
T0679	Ketoconazole	Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T0792	(-)-Sparteine sulfate pentahydrate	Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0920	Ambroxol	Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosol...
T1011	Itraconazole	Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T1149	Fenofibrate	Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
T1187	Bifonazole	Bifonazole acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a ...
T1274	Benzbromarone	Benzbromarone is a CYP2C9 inhibitor with Ki value of 19.3 nM.
T1597	Proadifen hydrochloride	Proadifen hydrochloride is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
T1704	Diosmetin	Diosmetin has been found to act as a weak TrkB receptor agonist.
T2143	Bergapten	Bergapten, a psoralen, inhibits cell replication.
T2175	Apigenin	Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothin...
T2532	Tauroursodeoxycholic Acid	Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeox...
T2753	Avasimibe	Avasimibe is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the ...
T2838	Naringenin	Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate m...
T2944	Sodium Danshensu	Danshensu (sodium salt) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstrictio...
T2949	Alizarin	Alizarin, a red dye derived from the roots of plants of the madder genus, inhibits P450 isoform CYP1A1( IC50 = 6.2 μM), CYP1A2 (IC50 =10.0 μM )and CYP1B1(IC50...
T3355	Naloxegol oxalate	Naloxegol oxalate is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
T3401	Ginsenoside F1	Ginsenoside F1 is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of t...
T3411	Curdione	Curdione inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Curdione may be ...
T3417	Amentoflavone	Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
T3585	TMS	TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
T3669	Curcumenol	Curcumenol, one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely us...
T3698	alpha-Asarone	Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T3776	Rhapontigenin	Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic arom...
T3797	Isosilybin	Isosilybin and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.
T3886	Rosavin	Rosavin has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.
T4188	SDZ285-428	NVP-VID-400 (SDZ285-428) is a CYP24A1 inhibitor.
T6030	XL388	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T6050	TAK-700	TAK-700 (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-h...
T6051	(S)-Orteronel	Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castr...
T6215	Abiraterone Acetate	Abiraterone acetate is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic...
T6216	Abiraterone	Abiraterone (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).
T6246	Cobicistat	Cobicistat is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with whic...
T6509	Galeterone	Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhib...
T2S0663	Humantenmine	1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
T5S2360	Corydaline	1. Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying an...
T6S1894	Linderane	1. Linderane was characterized as a mechanism-based inactivator of CYP2C9.