P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T16739	RG-12525	120128-20-3	98%
T16739	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN4800	Pisatin	20186-22-5	98%
TN4800	Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
T11065	DMU2105	1821143-79-6	98%
T11065	DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
TN2179	Saponarin	20310-89-8	98%
TN2179	Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T11066	DMU2139	1821143-80-9	98%
T11066	DMU2139 is a potent and specific CYP1B1 inhibitor with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
TQ0109	Cephaeline dihydrochloride	5853-29-2	98%
TQ0109	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T10535	BI 653048	1198784-72-3	98%
T10535	BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
TQ0276	Methysticin	20697-20-5	98%
TQ0276	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN3875	Dipterocarpol	471-69-2	98%
TN3875	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN3147	6',7'-Dihydroxybergamottin	264234-05-1	98%
TN3147	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN5278	Zederone	7727-79-9	98%
TN5278	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TMA2106	(-)-Sparteine	24915-04-6	98%
TMA2106	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate	67667-71-4	98%
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN3379	Allocryptopine	24240-04-8	98%
TN3379	Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyto...
TN2687	2,3',4,6-Tetrahydroxybenzophenone	26271-33-0	98%
TN2687	2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
TN3574	Canadine	5096-57-1	98%
TN3574	Canadine has antioxidant activity with low-toxic effect.
T14678	BMS-819881	1197420-05-5	98%
T14678	BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
TN4424	Lecanoric acid	480-56-8	98%
TN4424	Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
T10891	CRTH2-IN-1	926661-54-3	98%
T10891	CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
TN4277	Isocupressic acid	1909-91-7	98%
TN4277	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...