P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T14678	BMS-819881	1197420-05-5	98%
T14678	BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
TN4130	Germacrone 4,5-epoxide	92691-35-5	98%
TN4130	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T10688	Casopitant mesylate	414910-30-8	98%
T10688	Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TN3574	Canadine	5096-57-1	98%
TN3574	Canadine has antioxidant activity with low-toxic effect.
TN3147	6',7'-Dihydroxybergamottin	264234-05-1	98%
TN3147	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN3627	Chalepensin	13164-03-9	98%
TN3627	Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
TN1748	Humantenirine	82375-30-2	98%
TN1748	Standard reference
T10535L	BI 653048 phosphate	1198784-97-2	98%
T10535L	BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
T11066	DMU2139	1821143-80-9	98%
T11066	DMU2139 is a potent and specific CYP1B1 inhibitor with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
TN1210	2-Hydroxy-1-Methoxyaporphine	33770-27-3	98%
TN1210	2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
TN3875	Dipterocarpol	471-69-2	98%
TN3875	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TQ0276	Methysticin	20697-20-5	98%
TQ0276	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN1526	Corydalmine	30413-84-4	98%
TN1526	Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
TN4435	Licopyranocoumarin	117038-80-9	98%
TN4435	Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
TN2687	2,3',4,6-Tetrahydroxybenzophenone	26271-33-0	98%
TN2687	2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
TN4928	Rutacridone	17948-33-3	98%
TN4928	Rutacridone has mutagenicity.
TN2144	Resveratroloside	38963-95-0	98%
TN2144	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TQ0296	N-Nornuciferine	4846-19-9	98%
TQ0296	N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
T11964	MCH-1 antagonist 1	1039825-68-7	98%
T11964	MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).
TN3080	5,6,7-Trimethoxycoumarin	55085-47-7	98%
TN3080	5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp l...