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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Cat. No. Product name CAS No. Purity Chemical Structure
T16739 RG-12525 120128-20-3 98%
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN4800 Pisatin 20186-22-5 98%
Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
T11065 DMU2105 1821143-79-6 98%
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
TN2179 Saponarin 20310-89-8 98%
Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T11066 DMU2139 1821143-80-9 98%
DMU2139 is a potent and specific CYP1B1 inhibitor with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
TQ0109 Cephaeline dihydrochloride 5853-29-2 98%
(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T10535 BI 653048 1198784-72-3 98%
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
TQ0276 Methysticin 20697-20-5 98%
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN3875 Dipterocarpol 471-69-2 98%
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN3147 6',7'-Dihydroxybergamottin 264234-05-1 98%
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN5278 Zederone 7727-79-9 98%
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TMA2106 (-)-Sparteine 24915-04-6 98%
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
TN3294 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 67667-71-4 98%
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN3379 Allocryptopine 24240-04-8 98%
Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyto...
TN2687 2,3',4,6-Tetrahydroxybenzophenone 26271-33-0 98%
2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
TN3574 Canadine 5096-57-1 98%
Canadine has antioxidant activity with low-toxic effect.
T14678 BMS-819881 1197420-05-5 98%
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
TN4424 Lecanoric acid 480-56-8 98%
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
T10891 CRTH2-IN-1 926661-54-3 98%
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
TN4277 Isocupressic acid 1909-91-7 98%
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
RG-12525
T16739
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
Pisatin
TN4800
Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
DMU2105
T11065
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
Saponarin
TN2179
Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
DMU2139
T11066
DMU2139 is a potent and specific CYP1B1 inhibitor with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
Cephaeline dihydrochloride
TQ0109
(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
BI 653048
T10535
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
Methysticin
TQ0276
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
Dipterocarpol
TN3875
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
6',7'-Dihydroxybergamottin
TN3147
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
(-)-Sparteine
TMA2106
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN3294
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
Allocryptopine
TN3379
Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyto...
2,3',4,6-Tetrahydroxybenzophenone
TN2687
2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
Canadine
TN3574
Canadine has antioxidant activity with low-toxic effect.
BMS-819881
T14678
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
Lecanoric acid
TN4424
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
CRTH2-IN-1
T10891
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
Isocupressic acid
TN4277
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
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