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TMS

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Catalog No. T3585Cas No. 24144-92-1
Alias 2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene

TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

TMS

TMS

🥰Excellent
Purity: 99.56%
Catalog No. T3585Alias 2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbeneCas No. 24144-92-1
TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$77In Stock
25 mg$153In Stock
50 mg$279In Stock
100 mg$416In Stock
500 mg$942In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
Targets&IC50
CYP1A1:300 nM (IC50), CYP1B1:3 nM (Ki), CYP1B1:6 nM (IC50), CYP1A2:3.1 μM (IC50)
In vitro
Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail).
In vivo
Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period
Alias2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene
Chemical Properties
Molecular Weight300.35
FormulaC18H20O4
Cas No.24144-92-1
SmilesCOc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1
Relative Density.1.117 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (166.47 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3294 mL16.6472 mL33.2945 mL166.4724 mL
5 mM0.6659 mL3.3294 mL6.6589 mL33.2945 mL
10 mM0.3329 mL1.6647 mL3.3294 mL16.6472 mL
20 mM0.1665 mL0.8324 mL1.6647 mL8.3236 mL
50 mM0.0666 mL0.3329 mL0.6659 mL3.3294 mL
100 mM0.0333 mL0.1665 mL0.3329 mL1.6647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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