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TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $77 | In Stock | |
25 mg | $153 | In Stock | |
50 mg | $279 | In Stock | |
100 mg | $416 | In Stock | |
500 mg | $942 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). |
Targets&IC50 | CYP1A1:300 nM (IC50), CYP1B1:3 nM (Ki), CYP1B1:6 nM (IC50), CYP1A2:3.1 μM (IC50) |
In vitro | Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail). |
In vivo | Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period |
Alias | 2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene |
Molecular Weight | 300.35 |
Formula | C18H20O4 |
Cas No. | 24144-92-1 |
Smiles | COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1 |
Relative Density. | 1.117 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (166.47 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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