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NO PAINS Compound Library

Catalog No. L4020
  Library Compound List   Excel SDF

High-throughput screening is an important research tool in drug discovery, which allows rapid testing of a large number of compounds to identify target compounds, where the potent compounds can act precisely at specific protein binding sites to inhibit or activate protein function. However, some compounds were found in high-throughput screening experiments that were not based on the specific interaction between the compound and the protein and showed false positive results for "activity" in different types of target screenings. These compounds are called PAINS, the abbreviation for “Pan-assay interference compounds”. Common PAINS compounds include toxoflavin, isothiazolones, rhodanines, enones etc. Since first publication in 2010 by John Bell, PAINS filters have become widely recognized by the drug discovery industry.

For scientists who needed the PAINS filter, TargetMol created the L4020 NO-PAINS Compound Library that applied the PAINS filter, remaining 9555 small molecules that are suitable for new drug development, signaling pathway research, drug repurposing and other research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • 9555 PAINS-excluded small molecules for high-throughput screening and high-content screening.
  • Diverse targets with wide coverage; covers multiple disease research areas such as cancer, metabolism, immune system and cardiovascular system.
  • An effective tool for drug repurposing and cell-induced target screening.
  • Detailed instructions, compound structures, target information, activity descriptions, etc.
  • Structural diversity, significant druggability and cell penetration.
  • NMR, HPLC/ LCMS testings to ensure accurate structure and high purity.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L4020)

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Library Composition

Apoptosis (877)
Autophagy (707)
Antibacterial (692)
Endogenous Metabolite (632)
Antibiotic (478)
5-HT Receptor (243)
AChR (216)
Parasite (210)
Antifungal (201)
COX (197)
NF-κB (184)
Adrenergic Receptor (168)
DNA/RNA Synthesis (166)
HIV Protease (150)
Potassium Channel (150)
Dopamine Receptor (148)
PI3K (138)
Calcium Channel (137)
CDK (137)
Reactive Oxygen Species (126)
VEGFR (118)
P450 (116)
Sodium Channel (112)
EGFR (111)
Histamine Receptor (110)
GABA Receptor (101)
Epigenetic Reader Domain (101)
Influenza Virus (101)
Dehydrogenase (101)
PDE (91)
HDAC (90)
Ferroptosis (85)
PPAR (85)
Microtubule Associated (82)
Estrogen/progestogen Receptor (81)
Histone Methyltransferase (81)
TRP/TRPV Channel (78)
GluR (78)
Antioxidant (73)
p38 MAPK (73)
FLT (73)
Opioid Receptor (72)
TNF (72)
mTOR (72)
AChE (71)
PDGFR (70)
ERK (69)
JAK (69)
Estrogen Receptor/ERR (69)
Src (68)
Phosphatase (65)
RAAS (64)
iGluR (63)
Topoisomerase (63)
FGFR (63)
Akt (63)
SARS-CoV (60)
PARP (60)
STAT (59)
HCV Protease (58)
Caspase (58)
GPR (58)
c-Kit (58)
Proteasome (57)
Wnt/beta-catenin (57)
Virus Protease (56)
Prostaglandin Receptor (56)
Raf (56)
AMPK (55)
Adenosine Receptor (55)
c-Met/HGFR (54)
PKC (53)
IL Receptor (53)
NMDAR (51)
MMP (51)
ATPase (50)
Glucocorticoid Receptor (49)
NO Synthase (49)
Mitophagy (49)
TGF-beta/Smad (48)
Beta Amyloid (48)
Bcr-Abl (48)
Ras (47)
ALK (47)
GSK-3 (46)
HSV (45)
BCL (45)
Androgen Receptor (45)
Mitochondrial Metabolism (44)
Anti-infection (43)
HSP (43)
HBV (42)
TLR (41)
Nucleoside Antimetabolite/Analog (41)
Tyrosinase (40)
MEK (39)
Drug Metabolite (38)
MAO (38)
Sirtuin (38)
Phospholipase (37)
ROS (37)
P2 Receptor (36)
JNK (36)
Reverse Transcriptase (35)
Interleukin (35)
P-gp (35)
Aurora Kinase (35)
Monoamine Oxidase (34)
Cannabinoid Receptor (34)
MAPK (34)
PKA (33)
IκB/IKK (33)
HER (33)
Glucokinase (33)
DNA-PK (33)
Lipoxygenase (33)
BTK (32)
Tyrosine Kinases (32)
Serotonin Transporter (31)
ROCK (31)
Integrin (31)
Antiviral (31)
ribosome (31)
HIF/HIF Prolyl-Hydroxylase (30)
Carbonic Anhydrase (30)
E1/E2/E3 Enzyme (29)
NOS (29)
CXCR (28)
Serine/threonin kinase (28)
CaMK (28)
Histone Demethylase (27)
Casein Kinase (27)
p53 (27)
TAM Receptor (27)
Gamma-secretase (27)
Trk receptor (26)
c-RET (26)
CCR (26)
Neurokinin receptor (25)
Chloride channel (25)
S1P Receptor (25)
LPL Receptor (25)
DNA Alkylator/Crosslinker (24)
Antifection (24)
Retinoid Receptor (24)
Proton pump (24)
FAK (24)
IGF-1R (24)
DUB (23)
S6 Kinase (23)
Norepinephrine (23)
Histone Acetyltransferase (22)
Hedgehog/Smoothened (22)
Serine Protease (22)
ATM/ATR (22)
Cysteine Protease (22)
HIF (21)
Fatty Acid Synthase (21)
Transferase (21)
Progesterone Receptor (20)
Indoleamine 2,3-Dioxygenase (IDO) (20)
PLK (20)
Glucagon Receptor (20)
c-Fms (20)
DPP-4 (20)
Amino Acids and Derivatives (20)
FXR (19)
NADPH (19)
FAAH (19)
Thyroid hormone receptor(THR) (19)
Chk (19)
HMG-CoA Reductase (19)
P2X Receptor (18)
DNA Methyltransferase (18)
Reductase (18)
RIP kinase (18)
Protease-activated Receptor (18)
transporter (17)
Aryl Hydrocarbon Receptor (17)
GNRH Receptor (17)
Guanylate cyclase (17)
LRRK2 (17)
Thrombin (16)
PDK (16)
Smo (16)
NOD (16)
Sigma receptor (16)
PERK (15)
Kinesin (15)
DNA Alkylation (15)
MRP (15)
AhR (15)
OX Receptor (15)
Nrf2 (15)
Melanocortin Receptor (15)
Acyltransferase (15)
Antifolate (15)
NOD-like Receptor (NLR) (14)
STING (14)
Neuropeptide Y Receptor (14)
SGLT (14)
Endothelin Receptor (14)
Factor Xa (13)
Glutathione Peroxidase (13)
Bradykinin Receptor (13)
Lipase (13)
Vasopressin Receptor (13)
Syk (13)
BACE (13)
Epoxide Hydrolase (13)
CFTR (13)
Mdm2 (13)
Immunology/Inflammation related (12)
DHFR (12)
ROR (12)
Rho (12)
DNA gyrase (12)
LTR (12)
PGE Synthase (12)
IRE1 (12)
c-Myc (12)
Hydroxylase (11)
Beta-Secretase (11)
Leukotriene Receptor (11)
DNA (11)
Aminopeptidase (11)
Complement System (11)
ABC (11)
IRAK (11)
CSF-1R (11)
GPCR19 (10)
Isocitrate Dehydrogenase (IDH) (10)
Liver X Receptor (10)
LPA Receptor (10)
GHSR (10)
Pim (10)
PAK (10)
Ephrin Receptor (10)
Myosin (10)
Stearoyl-CoA Desaturase (SCD) (10)
PD-1/PD-L1 (9)
IDO (9)
Gap Junction Protein (9)
IAP (9)
Xanthine Oxidase (8)
Aromatase (8)
Arginase (8)
Acetyl-CoA Carboxylase (8)
PAD (8)
cholecystokinin (8)
RSV (8)
Phosphorylase (8)
CAT (8)
IFNAR (8)
DYRK (8)
Monocarboxylate transporter (8)
Lipid (8)
NAMPT (8)
Porcupine (7)
GST (7)
PAI-1 (7)
UGT (7)
Discoidin Domain Receptor (DDR) (7)
Neprilysin (7)
Melatonin Receptor (7)
MLK (7)
Monoamine Transporter (7)
ATP Citrate Lyase (7)
cAMP (7)
PKM (6)
Telomerase (6)
PI4K (6)
Tie-2 (6)
Platelet aggregation (6)
YAP (6)
Oxytocin Receptor (6)
CaSR (6)
BCRP (6)
Neurotensin Receptor (6)
p97 (6)
GRK (6)
GTPase (6)
CRM1 (6)
MNK (6)
SGK (5)
Somatostatin (5)
CGRP Receptor (5)
LDL (5)
LIM Kinase (5)
TOPK (5)
DprE1 (5)
CETP (5)
MT Receptor (5)
PYK2 (5)
Na+/Ca2+ Exchanger (5)
CRISPR/Cas9 (5)
Free radical scavengers (5)
ACK (5)
NPC1L1 (5)
OCT (5)
ASK (4)
FLAP (4)
GlyT (4)
Carboxypeptidase(CPG2) (4)
PAFR (4)
advanced glycation end products (4)
PTEN (4)
APC (4)
cell cycle arrest (4)
Cell wall (4)
Annexin A (4)
Bombesin Receptor (4)
Adenylyl cyclase (4)
Adenosine deaminase (4)
cGAS (4)
OAT (4)
OXPHOS (4)
Glutaminase (4)
Thrombopoietin Receptor (3)
SIK (3)
Dynamin (3)
Decarboxylase (3)
Hippo pathway (3)
Glutathione reductase (3)
BMI-1 (3)
NEDD8 (3)
MyD88 (3)
MTH1 (3)
VDAC (3)
MELK (3)
Adiponectin receptor (3)
MAGL (3)
TSH Receptor (3)
KLF (3)
Pyroptosis (3)
Hexokinase (3)
GPX (3)
CRFR (3)
VDA (2)
Apelin receptor (2)
Aquaporin (2)
Wee1 (2)
Integrase (2)
Survivin (2)
GluCls (2)
RAR/RXR  (2)
Hck (2)
lysosomal autophagy (2)
MALT (2)
Haspin Kinase (2)
Melanin-concentrating Hormone Receptor (MCHR) (2)
Galectin (2)
KSP (2)
NADPH-oxidase (2)
Na-K-Cl cotransporter (2)
EBI2/GPR183 (2)
LHRH (2)
Motilin Receptor (1)
N-Acetylglucosaminyltransferase (1)
aconitase (1)
Anion Exchanger (1)
NMU2R (1)
HCN Channel (1)
Hydrogenase (1)
Stemness kinase (1)
Transaminase (1)
hCE (1)
gp120/CD4 (1)
Fer/FerT kinase (1)
Fas/FasL (1)
FABP (1)
Thioredoxin (1)
CYP19A1 (1)
Taste receptor (1)
FOXO1 (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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