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Epacadostat

🥰Excellent
Catalog No. T3548Cas No. 1204669-58-8
Alias INCB 024360, IDO Inhibitor 1

Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.

Epacadostat

Epacadostat

🥰Excellent
Purity: 100%
Catalog No. T3548Alias INCB 024360, IDO Inhibitor 1Cas No. 1204669-58-8
Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$64In Stock
25 mg$89In Stock
50 mg$113In Stock
100 mg$197In Stock
200 mg$328In Stock
500 mg$553In Stock
1 g$796In Stock
2 g$1,090In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.
Targets&IC50
IDO1:10 nM
In vitro
METHODS: Epacadostat (INCB 024360) (0.0001, 0.01, 1, 100, 10000nM) was used to treat SKOV-3 cells and the release of kynurenine was measured.
RESULTS Epacadostat (INCB 024360) inhibited the catalytic activity of IDO1 with an IC50 value of 17.63 nM ± 2.26 (pIC50 = 7.76 ± 0.06). [2]
In vivo
METHODS: Mice were injected subcutaneously with 200 μl TC-1 cells on the back. After the tumor was palpable, Epacadostat (INCB 024360) (50 mg/kg), IFN-γ (100 ng/mouse), and kynurenine (100 mg/kg) were injected intraperitoneally every day. Tumor volume was measured every 3 days.
RESULTS Intraperitoneal injection of Epacadostat (INCB 024360) caused a significant increase in tumor volume and tumor weight, and inhibited the expression of CD80 on macrophages in tumor tissues. [3]
Cell Research
INCB 024360 (INCB024360) is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. To determine INCB 024360 activity against IDO in recombinant cells, HEK293/MSR cells are transiently transfected with full-length human or mouse IDO1, or mouse IDO2 cDNA, with Transit-293 transfection reagent or Lipofectamine 2000 reagents. INCB 024360 at different concentrations is added to the recovered transfected cells seeded at 2×104 cells per well in a 96-well plate (200 μL/well). The cells are incubated for 2 days, and kyn in the supernatants is measured as described in the HeLa cell assay. The tryptophan 2,3-dioxygenase (TDO) assay is performed similarly with HEK293/MSR cells transfected with a human TDO expression vector[1].
AliasINCB 024360, IDO Inhibitor 1
Chemical Properties
Molecular Weight438.23
FormulaC11H13BrFN7O4S
Cas No.1204669-58-8
SmilesNS(=O)(=O)NCCNc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O
Relative Density.2.01 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 53 mg/mL (120.94 mM)
DMSO: 50 mg/mL (114.1 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.2819 mL11.4095 mL22.8191 mL114.0953 mL
5 mM0.4564 mL2.2819 mL4.5638 mL22.8191 mL
10 mM0.2282 mL1.1410 mL2.2819 mL11.4095 mL
20 mM0.1141 mL0.5705 mL1.1410 mL5.7048 mL
50 mM0.0456 mL0.2282 mL0.4564 mL2.2819 mL
100 mM0.0228 mL0.1141 mL0.2282 mL1.1410 mL

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