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PEG300

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Catalog No. T7022Cas No. 25322-68-3
Alias Polyethylene glycol 300

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

PEG300

PEG300

🥰Excellent
Catalog No. T7022Alias Polyethylene glycol 300Cas No. 25322-68-3
PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
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100 mL$48In Stock
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Purity:mw~300
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Product Introduction

Bioactivity
Description
PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
In vitro
METHODS: Human colorectal adenocarcinoma cells Caco-2 were treated with PEG300 (30 w/v% in 100 μL) for 30 min, and cell growth inhibition was detected by MTT.
RESULTS: PEG300 treatment severely reduced cell viability, and the cell survival rate was only 20%. [1]
In vivo
METHODS: To study the effect of Dasatinib on diabetic cardiomyopathy, Dasatinib (5 mg/kg in 10% DMSO + 90% PEG-300) was administered by gavage to BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice once a week for four weeks.
RESULTS: Dasatinib counteracted obesity in the heart and bone marrow as well as cardiac fibrosis. [2]
METHODS: To test the in vivo effects of treatment with ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab, cetuximab (25 mg/kg in 10% 1-methyl-2-pyrrolidinone + 90% PEG 300 twice weekly) and ALW-II-41-27 (30 mg/kg/day) were injected intraperitoneally into balb/c athymic (nu+/nu+) mice bearing human colorectal adenocarcinoma tumor HCT15 for six weeks.
RESULTS: The combination of ALW-II-41-27 and cetuximab significantly inhibited tumor growth. [3]
AliasPolyethylene glycol 300
Chemical Properties
Molecular Weight300
Cas No.25322-68-3
Relative Density.1.1 g/cm3. Temperature:30 °C.
Storage & Solubility Information
Storagestore at 4°C | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (333.33 mM), Sonication is recommended.
H2O: 50 mg/mL (166.67 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3333 mL16.6667 mL33.3333 mL166.6667 mL
5 mM0.6667 mL3.3333 mL6.6667 mL33.3333 mL
10 mM0.3333 mL1.6667 mL3.3333 mL16.6667 mL
20 mM0.1667 mL0.8333 mL1.6667 mL8.3333 mL
50 mM0.0667 mL0.3333 mL0.6667 mL3.3333 mL
100 mM0.0333 mL0.1667 mL0.3333 mL1.6667 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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