DOSE CONVERSION BETWEEN ANIMALS AND HUMAN

Dose conversion

Table 1. Animal equivalent dose calculation based on Km ratio.

Note

• The Km ratio values provided in Table 1 is easily obtained by dividing one animal species Km factor by another animal species Km factor or vice versa. The correction factor (Km) is estimated by dividing the average body weight (kg) of species to its body surface area (m2).
• However, it must be borne in mind that the km factor varies across animal species and increases proportional to W2/3 within a species as body weight increases. For example, the km value in ratsvaries from 5.2 (100 g rat), 6 (150 g rat), and 7 (250 g rat).
• Although Table 1. indicates the dose conversion of the drug injection between human and animals, allproducts offered by our company could only be used for researches on cells or experimental animals. They are strictly prohibited to be used on any human, and usage as veterinary drug or pesticide isalso not allowed.
• The animal equivalent dose (AED) can be calculated on the basis of body surface area ratio (BSA ratio) provided in the Table 2 (Eq.2).

Table 2. Animal equivalent dose calculation based on BSA ratio.

Note

• The BSA ratio values provided in Table 2 is easily obtained by dividing one animal BSA by another animal BSA or vice versa. Body surface areas are calculated by Meeh's formula: BSA = k(W)2/3 and they are proportionate to the two-thirds power of their weight.
  Where: K = 9.0 for mice; K = 10.4 for cats; K = 10.1 for dogs; K = 10.5 for guinea pigs; K = 12.0-12.9 for rabbits; K = 9.0 for laboratory rats; K = 11.8 for monkeys; K = 10.6 for adults(human).

References

• Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27-31. doi:10.4103/0976-0105.177703
• Price GS and Frazier DL. Use of Body Surface Area (BSA)-Based Dosages to Calculate Chemotherapeutic Drug Dose in Dogs: I. Potential Problems with Current BSA Formulae. J Vet Intern Med. 1998;12:267-271.
• Wynn SG, Fougere B. Chapter 14: Herb manufacture, Pharmacy, and Dosing. In: Wynn SG, Fougere B, eds. Veterinary Herbal Medicine. St. Louis, MO: Elsevier; 2007: 233-235.
• 4.Chappell WR, Mordenti J. Extrapolation of toxicological and pharmacological data from animals to humans. In: Testa B, eds. Advances in drug research Volume 20. San Diego, CA: Academic Press; 1991: 15-26.