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Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620
  Library Compound List   Excel SDF

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 1622 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1622 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2620)

Library Composition

5-HT Receptor (238)
AChR (193)
Adrenergic Receptor (184)
Dopamine Receptor (152)
GABA Receptor (95)
Opioid Receptor (65)
PDE (59)
NMDAR (46)
GluR (45)
Histamine Receptor (43)
Beta Amyloid (33)
PPAR (33)
JNK (33)
GSK-3 (30)
Gamma-secretase (24)
Norepinephrine (23)
MAO (22)
Caspase (22)
NF-κB (21)
Potassium Channel (20)
LRRK2 (18)
Adenosine Receptor (17)
Calcium Channel (16)
P450 (15)
TNF (14)
Sodium Channel (13)
CDK (12)
Endogenous Metabolite (11)
BACE (11)
COX (11)
Dehydrogenase (10)
Bcr-Abl (10)
Apoptosis (9)
Autophagy (9)
Cannabinoid Receptor (8)
ROS (8)
Estrogen/progestogen Receptor (8)
Nrf2 (7)
IL Receptor (7)
c-Kit (7)
ERK (7)
p38 MAPK (7)
Src (7)
Transferase (6)
Sirtuin (6)
BCL (6)
Phosphatase (6)
IκB/IKK (6)
Mitochondrial Metabolism (6)
Microtubule Associated (6)
Antifection (6)
EGFR (6)
PI3K (5)
Sigma receptor (5)
Aurora Kinase (5)
MRP (5)
FLT (5)
Akt (5)
MMP (5)
S1P Receptor (5)
Antioxidant (5)
DNA/RNA Synthesis (4)
Serotonin Transporter (4)
CCR (4)
NOS (4)
Epigenetic Reader Domain (4)
iGluR (4)
Vitamin (4)
VEGFR (4)
Tyrosinase (4)
MEK (4)
CaMK (4)
HDAC (4)
IGF-1R (3)
Chloride channel (3)
Integrin (3)
Glucokinase (3)
Lipoxygenase (3)
ABC (3)
HMG-CoA Reductase (3)
TGF-beta/Smad (3)
TRP/TRPV Channel (3)
Histone Methyltransferase (3)
Cysteine Protease (3)
JAK (3)
Carbonic Anhydrase (3)
Wnt/beta-catenin (3)
Antifungal (3)
Phospholipase (3)
PKA (3)
PKC (3)
Parasite (3)
AMPK (3)
p53 (3)
PARP (3)
Retinoid Receptor (3)
Amino Acids and Derivatives (3)
S6 Kinase (3)
NADPH (3)
NOD (3)
Antiviral (3)
BTK (2)
Immunology & Inflammation related (2)
ATPase (2)
FGFR (2)
HIV Protease (2)
Histone Demethylase (2)
PAFR (2)
Free radical scavengers (2)
Androgen Receptor (2)
Glucocorticoid Receptor (2)
Antibacterial (2)
HIF (2)
Antibiotic (2)
LDL (2)
GPR (2)
mTOR (2)
Casein Kinase (2)
Rho (2)
Trk receptor (2)
CGRP Receptor (2)
UGT (2)
advanced glycation end products (2)
cAMP (2)
c-Met/HGFR (2)
CSF-1R (2)
Raf (2)
Decarboxylase (2)
AChE (2)
RAAS (2)
DNA Alkylation (2)
Topoisomerase (2)
ATM/ATR (1)
Acyltransferase (1)
Aromatase (1)
Keap1-Nrf (1)
Monoamine Transporter (1)
Thrombin (1)
transporter (1)
Adenylyl cyclase (1)
Adiponectin receptor (1)
Liver X Receptor (1)
TLR (1)
MAPK (1)
Mdm2 (1)
Transaminase (1)
Annexin A (1)
MLK (1)
ALK (1)
Telomerase (1)
Beta-Secretase (1)
Monocarboxylate transporter (1)
Reactive Oxygen Species (1)
FAAH (1)
PDGFR (1)
P-gp (1)
DYRK (1)
Prostaglandin Receptor (1)
RAR/RXR (1)
cholecystokinin (1)
FXR (1)
c-Fms (1)
Reverse Transcriptase (1)
ROR (1)
SGLT (1)
STAT (1)
Syk (1)
Ferroptosis (1)
PAI-1 (1)
MT Receptor (1)
NPC1L1 (1)
IAP (1)
Hydroxylase (1)
HSP (1)
Na-K-Cl cotransporter (1)
Histone Acetyltransferase (1)
HER (1)
Hck (1)
Gap Junction Protein (1)
GST (1)
Nucleoside Antimetabolite/Analog (1)
GRK (1)
GlyT (1)
P2 Receptor (1)
GluCls (1)
HCV Protease (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE