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Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620
  Library Compound List   Excel SDF

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
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Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS；
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.；
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description；
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L2620)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

5-HT Receptor (297)
AChR (283)
Dopamine Receptor (241)
Adrenergic Receptor (209)
GABA Receptor (143)
Apoptosis (137)
GluR (127)
Autophagy (127)
Opioid Receptor (96)
AChE (95)
Endogenous Metabolite (90)
Histamine Receptor (86)
NMDAR (85)
PDE (74)
iGluR (71)
Beta Amyloid (68)
MAO (57)
COX (54)
Gamma-secretase (44)
Monoamine Oxidase (44)
JNK (41)
Serotonin Transporter (39)
Reactive Oxygen Species (39)
Antibacterial (39)
NF-κB (36)
PPAR (35)
Norepinephrine (34)
Potassium Channel (33)
Adenosine Receptor (33)
GSK-3 (33)
Sodium Channel (29)
Caspase (28)
Calcium Channel (26)
P450 (22)
Parasite (22)
Influenza Virus (21)
TNF (19)
CaMK (18)
Nrf2 (18)
LRRK2 (17)
HIV Protease (17)
BACE (16)
Mitophagy (16)
Ferroptosis (14)
ERK (14)
CDK (14)
Antifungal (13)
Mitochondrial Metabolism (12)
Antibiotic (12)
Beta-Secretase (12)
IL Receptor (11)
Dehydrogenase (11)
Cannabinoid Receptor (11)
TRP/TRPV Channel (11)
Akt (10)
Phosphatase (10)
Transferase (10)
Bcr-Abl (10)
Src (9)
DNA/RNA Synthesis (9)
p38 MAPK (9)
ROS (9)
NO Synthase (9)
Imidazoline Receptor (8)
MMP (8)
Sigma receptor (8)
GlyT (8)
Estrogen/progestogen Receptor (8)
Phospholipase (8)
PI3K (8)
FLT (7)
Interleukin (7)
Microtubule Associated (7)
BCL (7)
PARP (7)
MRP (7)
Virus Protease (7)
Antioxidant (7)
IκB/IKK (7)
OX Receptor (7)
P2X Receptor (6)
Drug Metabolite (6)
Aurora Kinase (6)
Lipoxygenase (6)
PKC (6)
Wnt/beta-catenin (6)
P-gp (6)
Sirtuin (6)
MT Receptor (6)
HDAC (6)
AMPK (6)
MEK (6)
c-Kit (6)
Adenylyl cyclase (6)
EGFR (5)
AAK1 (AP2 associated kinase 1) (5)
S1P Receptor (5)
FAAH (5)
PKA (5)
Chloride channel (5)
LPL Receptor (5)
VEGFR (5)
Histone Demethylase (5)
Melatonin Receptor (5)
ROR (4)
FGFR (4)
IGF-1R (4)
CCR (4)
HSV (4)
RAAS (4)
Neurokinin receptor (4)
mTOR (4)
Histone Methyltransferase (4)
JAK (4)
Anti-infection (4)
Retinoid Receptor (4)
HMG-CoA Reductase (4)
Tyrosinase (4)
Carbonic Anhydrase (4)
NOS (4)
Trk receptor (4)
ABC (4)
Epigenetic Reader Domain (4)
NADPH (3)
TGF-beta/Smad (3)
Casein Kinase (3)
Rho (3)
MAPK (3)
c-Fms (3)
Estrogen Receptor/ERR (3)
Epoxide Hydrolase (3)
HER (3)
Glucosidase (3)
p53 (3)
Amino Acids and Derivatives (3)
Glucocorticoid Receptor (3)
HIF/HIF Prolyl-Hydroxylase (3)
NOD (3)
S6 Kinase (3)
DYRK (2)
RSV (2)
Free radical scavengers (2)
transporter (2)
NOD-like Receptor (NLR) (2)
Decarboxylase (2)
Transaminase (2)
Ras (2)
ATM/ATR (2)
Progesterone Receptor (2)
IFNAR (2)
Reverse Transcriptase (2)
Gap Junction Protein (2)
STAT (2)
Integrin (2)
CRISPR/Cas9 (2)
c-Met/HGFR (2)
GPR (2)
CGRP Receptor (2)
STING (2)
Raf (2)
Histone Acetyltransferase (2)
Prostaglandin Receptor (2)
Cysteine Protease (2)
PAFR (2)
UGT (2)
BTK (2)
Antifection (2)
Monoamine Transporter (2)
Guanylate cyclase (2)
Topoisomerase (2)
Stearoyl-CoA Desaturase (SCD) (2)
CSF-1R (2)
Immunology/Inflammation related (2)
Aryl Hydrocarbon Receptor (2)
FXR (2)
advanced glycation end products (2)
HBV (2)
Antiviral (2)
Annexin A (1)
HCV Protease (1)
Proteasome (1)
PAK (1)
NMU2R (1)
DNA Alkylation (1)
Syk (1)
Bombesin Receptor (1)
PDGFR (1)
NPC1L1 (1)
Neuropeptide Y Receptor (1)
IRAK (1)
GRK (1)
Serine/threonin kinase (1)
E1/E2/E3 Enzyme (1)
Chk (1)
OCT (1)
Adiponectin receptor (1)
Thrombin (1)
OAT (1)
Hexokinase (1)
FAK (1)
Acyltransferase (1)
SARS-CoV (1)
MLK (1)
ATPase (1)
TLR (1)
LDL (1)
Monocarboxylate transporter (1)
PGE Synthase (1)
SGLT (1)
DNA (1)
ALK (1)
GTPase (1)
Neprilysin (1)
Telomerase (1)
GST (1)
Glutathione Peroxidase (1)
Liver X Receptor (1)
Nucleoside Antimetabolite/Analog (1)
Androgen Receptor (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
PAI-1 (1)
DUB (1)
Aromatase (1)
RANKL/RANK (1)
SGK (1)
ROCK (1)
PDK (1)
GluCls (1)
RAR/RXR  (1)
Hck (1)
Na+/Ca2+ Exchanger (1)
Hydroxylase (1)
HSP (1)
HIF (1)
Adenosine deaminase (1)
DNA Alkylator/Crosslinker (1)
PAD (1)
IAP (1)
Somatostatin (1)
Arrestin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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