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KRH102140
🥰Excellent
Catalog No. T68511Cas No. 864769-01-7
Alias KRH 102140
KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.
KRH102140
🥰Excellent
Purity: 99.61%
Catalog No. T68511Alias KRH 102140Cas No. 864769-01-7
KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $330 | In Stock | |
| 5 mg | $790 | In Stock | |
| 10 mg | $1,120 | In Stock | |
| 25 mg | $1,670 | In Stock | |
| 50 mg | $2,180 | In Stock |
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Purity:99.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research. |
| Targets&IC50 | 5-LOX:160 nM |
| In vitro | KRH102140 is a PHD2 activator that effectively inhibits HIF-1α in hypoxic human osteosarcoma cells. In addition, KRH102140 reduced mRNA levels of downstream target genes of HIF regulation related to angiogenesis and energy metabolism. [1] KRH102140 inhibited 5-LO activity with an IC50 value of 160 ± 23 nmol/l and inhibited LTB in RBL-1 cells. [2] |
| In vivo | Oral administration of KRH102140 (10-100 mg/kg) reduced ear edema, myeloperoxidase activity, and LTB production in a mouse inflammatory model. The oral bioavailability of rats was 66%. [2] |
| Alias | KRH 102140 |
| Molecular Weight | 373.46 |
| Formula | C25H24FNO |
| Cas No. | 864769-01-7 |
| Smiles | FC=1C=CC=CC1CNC=2C=CC=3OC(C=CC3C2)(C)CCC=4C=CC=CC4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (267.77 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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