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Microbiology/Virologyribosome
Ribosomes are macromolecular machines, found within all living cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the translational apparatus.
Puromycin dihydrochloride
Cited
T221958-58-2
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
- $39
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CitedDoxycycline Cited
T1687564-25-0
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
- $45
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CitedHygromycin B Cited
T102231282-04-9
Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic or eukaryotic cells transfected with hph or hyg resistance genes.
- $48
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CitedDoxycycline (hyclate)
T1687L24390-14-5
Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor activity.
- $41
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Tetracycline Cited
T0912L60-54-8
Tetracycline (Tetracyclin) is a broad-spectrum antibiotic with inhibitory activity against a wide range of Gram-positive and Gram-negative bacteria, as well as Mycoplasma, Mycoplasma, and Rickettsia. Tetracycline is commonly used in anti-infective studies.
- $33
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CitedChloramphenicol Cited
T120556-75-7
Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds.
- $40
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CitedTigecycline
T1569220620-09-7
Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline that binds to the 30S ribosomal subunit, disrupting the binding of aminoacyl-tRNA to the mRNA-ribosome complex.
- $32
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Omadacycline Cited
T5189389139-89-3
Omadacycline (Amadacycline), a new tetracycline antibiotic, can inhibit the 30s subunit of bacterial ribosome.
- $51
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CitedKanamycin sulfate
T079325389-94-0
Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
- $41
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Clarithromycin Cited
T143481103-11-9
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
- $50
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CitedAmikacin
T101337517-28-5
Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin.
- $30
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Azithromycin hydrate
T1419117772-70-0
Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
- $36
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Tobramycin
T125532986-56-4
Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.
- $33
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Erythromycin Cited
T1032114-07-8
Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.
- $44
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CitedMethacycline hydrochloride
T05183963-95-9
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
- $52
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Lefamulin acetate
T118361350636-82-6
Lefamulin acetate (BC-3781 acetate) (formally BC-3781 acetate) is a novel pleuromutilin antibiotic and is the first to be used for the systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer. Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment.
- $98
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Amikacin sulfate
T3125149022-22-0
Amikacin sulfate is a broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and ototoxic like the other aminoglycoside antibiotics.
- $30
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Spectinomycin dihydrochloride pentahydrate
T0788L22189-32-8
Spectinomycin dihydrochloride pentahydrate (Spectogard) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
- $50
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Roxithromycin Cited
T115180214-83-1
Roxithromycin (RU-28965) is a semi-synthetic macrolide antibiotic derived from erythromycin, exhibiting both antibacterial and anti-malarial properties.
- $50
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CitedAcetylspiramycin Cited
T155724916-51-6
Acetylspiramycin (Spiramycin B) targets 50S ribosome to inhibit protein synthesis.
- $35
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CitedClindamycin phosphate
T114224729-96-2
Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate (Clindamycin 2-dihydrogen phosphate) is used in topical preparations.
- $48
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Erythromycin ethylsuccinate
T04741264-62-6
Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.
- $35
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KKL-10
T4222952849-76-2
KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria.
- $44
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Dirithromycin
T097162013-04-1
Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.
- $31
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Retapamulin
T6638224452-66-8
Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).
- $32
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Kanamycin A
T0793L59-01-8
Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin is an aminoglycoside bacteriocidal antibiotic and used to treat a wide variety of infections. Kanamycin interacts with the
- $31
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