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TargetMol | Tags Endocrinology/Hormones
TargetMol | Tags Metabolism

Reductase

Reductase is an enzyme that catalyzes a reduction reaction.

Epristeride
T15239119169-78-7In house
Epristeride (ONO-9302) is an orally active, selective and non-competitive steroidal 5-α-reductase isoform 2 inhibitor that inhibits SR isoform 2.Episteride reduces prostate size and improves symptoms in men with BPH.Episteride induces atrophy and apoptosis of the ventral prostate in rats.
  • $100 TargetMol
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Isoliquiritigenin
T0725961-29-5
Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
  • $50
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TargetMol | Citations Cited
Alconil
T2984497677-19-5In house
Alconil (Al 1567) is an aldose reductase inhibitor that may be used to study chronic obstructive pulmonary disease (COPD) and diabetes.
  • $293 TargetMol
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Sorbinil
T1691068367-52-2
Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway.
  • $39
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MK 0434
T33414134067-56-4In house
MK 0434 is an orally active steroidal 5 alpha-reductase inhibitor.
  • $293 TargetMol
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Ginsenoside Ro
T391534367-04-9
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.
  • $64
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Engeletin
T6S0840572-31-6
1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
  • $41
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Ranirestat
T16723147254-64-6In house
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
  • $399
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Ganoderic acid C2
TN1661103773-62-2
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.
  • $55
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beta-Glucogallin
T12602213405-60-2
beta-Glucogallin (beta-Glucogallin) is a selective aldose reductase (AKR1B1) inhibitor with antioxidant, anti-glycation, and anti-inflammatory properties. beta-Glucogallin is a naturally occurring compound derived from Emblica officinalis and is used in diabetes research. Vitamin B3-d4
  • $56
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Dutasteride
T1499164656-23-9
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
  • $32
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TargetMol | Citations Cited
2'-acetylacteoside
T610294492-24-7
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smooth muscle, indicates that it may ha
  • $60
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Gonadorelin Acetate (33515-09-2 free base)
T501571447-49-9
Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.
  • $34
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DL-Glyceraldehyde
T491856-82-6
DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.
  • $47
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AT-007
T103932170729-29-8
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
  • $60
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Epalrestat
T145882159-09-9
Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control.
  • $30
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TargetMol | Citations Cited
Ponalrestat
T201372702-95-5
Ponalrestat is an aldose reductase inhibitor.
  • $39
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D-Methionine sulfoxide
T1926521056-56-4In house
D-Methionine sulfoxide inhibits peptide methionine sulfoxide reductase and can be used to inhibit ochre mites.D-Methionine sulfoxide can be added to chicken feed to promote growth.
  • $41
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Poliumoside
T6S238494079-81-9
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumos
  • $47
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Isocurcumenol
T5S054324063-71-6
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
  • $64
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Alpha-Estradiol
T337857-91-0
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
  • $50
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Aldose reductase-IN-1
T141751355612-71-3
Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase with an IC50 value of 28.9 pM, which can target the relaxin hormone signaling pathway in prostate cancer models.
  • $52
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Tectoridin
T3665611-40-5
Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin and its five metabolites inhibits the activities of lens aldose reductase in rat (IC : 1.4-15.5 μM).
  • $70
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6-Hydroxyluteolin
T7900518003-33-3
6-Hydroxyluteolin, a flavonoid compound prepared from the above-ground parts of Salvia amarissima Ortega, inhibits aldose reductase (AR), exhibits antimicrobial activity, and can be used in the study of bronchiectasis and wet gastric diseases.
  • $293
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BYAKANGELICIN
T5813482-25-7
BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use.
  • $31
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Finasteride
T048898319-26-7
Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
  • $35
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Tolrestat
T1711482964-04-3In house
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
  • $40
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Quercetin 3-gentiobioside
TN21227431-83-6
Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and the formation of advanced glycosylation end products (AGEs).
  • $109
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Zopolrestat
T35317110703-94-1
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
  • $30
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6-Methoxytricin
T1018376015-42-4
6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.
  • $65
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Lidorestat
T15756245116-90-9In house
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
  • $40
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Sulindac sulfone
T2340359864-04-9
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac.
  • $50
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Alrestatin
T519551411-04-2
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
  • $38
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12-O-Methylcarnosic acid
TN260162201-71-2
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity, it is effective preventing gastric lesions. 12-O-Methylcarnosic acid can suppress melanin production with downregulation of Tyrosinase expression in HMV-II melanoma cells. 12-O-Methylcarnosic acid may have anti-diabetic activity, it is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ.
  • $98
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Izonsteride
T27643176975-26-1In house
Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, and may be used in the study of prostate cancer.
  • $160
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Minalrestat
T33389129688-50-2In house
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
  • $258
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Turosteride
T71703137099-09-3In house
Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and genitourinary disorders, and may be used in the study of prostate cancer.
  • $130
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Isomer-Turosteride
T71703L In house
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to DHT.Isomer-Turosteride induces a decrease in prostate DHT independent of a secondary increase in T. Isomer-Turosteride has anticancer activity and inhibits the growth of tumor cells. Turosteride has anticancer activity and inhibits the growth of tumor cells. Translated with www.DeepL.com Translator (free version)
  • $195
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Imirestat
T1556889391-50-4
Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.
  • $74
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2-Chloro-1-(4-fluorobenzyl)benzimidazole
T747884946-20-3
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).
  • $31
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(R)-Viloxazine Hydrochloride
T2241356287-63-9
(R)-Viloxazine Hydrochloride is the R-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant.
  • $70
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EBPC
T227574450-98-0
EBPC is an inhibitor of aldose reductase.
  • $52
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WJ-39
T843453009908-95-3
WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).
  • $117
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ALR2-IN-1
T775232799695-54-6
ALR2-IN-1 is a potent and selective ALR2 inhibitor with an IC50 value of 1.42 μM. ALR2-IN-1 possesses both antiglycemic and antioxidant activities and can be used to study the complications of diabetes.
  • $33
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Risarestat
T1675679714-31-1
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
  • $165
6-8 weeks
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Triptocalline A
TN5183201534-10-3
Triptocalline A, a compound from Salacia chinensis, inhibits rat lens aldose reductase.
  • $1,879
7-10 days
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Danshenol A
TN3760189308-08-5
Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines.
  • $1,786
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Fidarestat
T15281136087-85-9
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
  • $268
35 days
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