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Cytoskeletal Signaling Pathway Compound Library

Catalog No. L1310
  Library Compound List   Excel SDF

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including bacteria and archaea. It extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. In eukaryotes, it is composed of three main components, microfilaments, intermediate filaments and microtubules, and these are all capable of rapid growth or disassembly dependent on the cell's requirements. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microtubules provide structure and shape to eukaryotic cells and help localize membrane-enclosed organelles. Intermediate filaments have great tensile strength, and their main function is to enable cells to withstand the mechanical stress that occurs when cells are stretched.

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, establishment of the intracellular organization of the cytoplasm, establishment of cell polarity, and many other functions that are essential for cellular homeostasis and survival. Many diseases have now been associated with abnormalities in cytoskeletal and nucleoskeletal proteins, including neurodegeneration such as Alzheimer's Disease (AD) with the accumulation of amyloid beta peptide, and the intracellular neurofibrillary tangles that composed of paired helical filaments of the microtubule-associated protein, tau; cancer (invasion) with cytoskeleton aberration like reduced microtubule polymerization, etc.

TargetMol’s Cytoskeletal Signaling Pathway Compound Library collects 590 compounds related to cytoskeletal regulation with targets on Microtubule/Tubulin, Kinesin, PKC, MAPK, etc. It can be used for research in cytoskeletal signaling pathway, cytoskeleton associated disease, and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Features

  • A unique collection of 590 cytoskeleton-related compounds, can be used for HTS and HCS;
  • Targets include Microtubule/Tubulin, Kinesin, PKC, MAPK, etc.;
  • Part of them are FDA-approved drugs;
  • Structural diversity with strong bioactivities and cell permeability;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1310)

Library Composition

Microtubule Associated (66)
PKC (58)
Akt (56)
Wnt/beta-catenin (52)
p38 MAPK (47)
HSP (47)
Bcr-Abl (47)
Integrin (30)
Src (27)
ROCK (22)
FAK (19)
PKA (18)
c-Kit (15)
MAPK (14)
ERK (14)
PDGFR (13)
Kinesin (13)
VEGFR (12)
NF-κB (12)
Apoptosis (11)
PAK (10)
CDK (9)
PI3K (9)
PPAR (8)
Aurora Kinase (7)
Caspase (7)
EGFR (7)
Gap Junction Protein (7)
FLT (6)
COX (6)
IGF-1R (6)
ATPase (6)
S6 Kinase (6)
FGFR (6)
JNK (5)
STAT (5)
Raf (5)
Autophagy (5)
PYK2 (5)
Endogenous Metabolite (4)
GPR (4)
ALK (4)
Dynamin (4)
Tyrosine Kinases (4)
MEK (4)
c-Met/HGFR (4)
AMPK (4)
S1P Receptor (4)
BCL (4)
Casein Kinase (4)
mTOR (4)
Serine/threonin kinase (4)
JAK (3)
BTK (3)
PARP (3)
LDL (3)
Estrogen/progestogen Receptor (3)
GSK-3 (3)
HIF (3)
c-Fms (3)
Myosin (3)
CaMK (3)
c-RET (3)
Topoisomerase (3)
Porcupine (2)
p53 (2)
P-gp (2)
Potassium Channel (2)
MLK (2)
PDK (2)
KSP (2)
Trk receptor (2)
AChR (2)
Rho (2)
Lipoxygenase (2)
Syk (2)
HIV Protease (2)
Epigenetic Reader Domain (2)
Calcium Channel (2)
Carbonic Anhydrase (2)
TNF (2)
DNA Alkylation (2)
DNA/RNA Synthesis (2)
Serine Protease (2)
Ephrin Receptor (2)
Adrenergic Receptor (2)
ACK (2)
Glucokinase (2)
GRK (2)
Hck (2)
SGK (2)
HER (2)
NADPH (2)
transporter (1)
Sodium Channel (1)
Tie-2 (1)
TGF-beta/Smad (1)
Vitamin (1)
TACC (1)
Nrf2 (1)
Parasite (1)
NAMPT (1)
Beta Amyloid (1)
PERK (1)
PLK (1)
PTEN (1)
RAAS (1)
Aminopeptidase (1)
Antibiotic (1)
Antioxidant (1)
Arginase (1)
Aromatase (1)
ASK (1)
DHFR (1)
MPO (1)
DNA (1)
GST (1)
HCV Protease (1)
Hedgehog/Smoothened (1)
Histamine Receptor (1)
IL Receptor (1)
IκB/IKK (1)
LRRK2 (1)
Mdm2 (1)
MMP (1)
MNK (1)
Gamma-secretase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE