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Necrostatin-1 (Nec-1)(Product No. T1847, CAS 4311-88-0) is a necroptosis inhibitor targeting RIPK1 and also an IDO inhibitor. Necrostatin-1 consists of a benzene ring, an aminothiazole ring, and an amide group. These structural features enable it to specifically bind to RIPK1 and inhibit its activity.

TargetMol will be a Gold Sponsor of the prestigious 2024 Harvard Chinese Life Science Annual Symposium, taking place on September 14, 2024. This annual event brings together leading researchers, industry professionals, and innovators from the global life sciences community, with a focus on advancements in biomedical research, biotechnology, and pharmaceutical sciences.

Bortezomibis a 20S proteasome inhibitor (Ki = 0.6 nM) with antitumor activity, capable of inhibiting NF-κB, disrupting the cell cycle, and inducing apoptosis

LY294002(SF 1101) is a broad-spectrum PI3K inhibitor that inhibits PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). It is also a DNA-PK inhibitor (IC50=1.4 μM) and a CK2 inhibitor (IC50=98 nM), and it can induce apoptosis and autophagy.

Insulin (human) (Product No. T8221, CAS 11061-68-0) is a polypeptide hormone secreted by pancreatic β-cells, with hypoglycemic activity. It promotes glycogen synthesis, regulates blood glucose levels, and is a key compound in maintaining the body's blood sugar balance.

Gemcitabine is a common pyrimidine nucleoside analog antimetabolite and antitumor agent. It targets and inhibits DNA synthesis, leading to autophagy and apoptosis.The chemical formula of gemcitabine is C9H11F2N3O4. Its core structure includes fluorine groups (specifically difluoro modifications) and an amino group. These two functional groups determine gemcitabine's pharmacological activity and stability. The design and development of prodrugs based on the amino group is also a current hot research topic.

Oxaliplatin is a chemical drug widely used in cancer treatment. As a platinum-based anticancer drug, oxaliplatin has achieved significant success in treating various types of cancer, particularly colorectal cancer. Its primary mechanism of action is through forming cross-links with DNA, thereby inhibiting DNA replication and transcription, ultimately leading to cancer cell death. Due to its unique molecular structure, oxaliplatin has relatively low nephrotoxicity, but its neurotoxicity is more pronounced.

Sorafenib (Cat No. T0093L, CAS 284461-73-0), also known as Bay 43-9006, is an orally active multi-kinase inhibitor. It targets several tumor-related kinases including CRAF, BRAF, c-Kit, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-β.

Chloroquine (CQ) is a commonly used antimalarial drug. In addition to its antimalarial properties, it is also used for anti-inflammatory, antiviral, and antitumor treatments. Its core structure is the 7-chloroquinoline ring.

20-Hydroxyeicosatetraenoic acid (hereinafter referred to as '20-HETE') is a long-chain fatty acid containing 20 carbon atoms.20-HETE is a metabolite of arachidonic acid (AA). AA, under the catalysis of the cytochrome P450 (CYP450) enzyme system, particularly the CYP4F2 enzyme, undergoes ω-hydroxylation to introduce a hydroxyl group at the C-20 position, thereby generating 20-HETE. The presence of this hydroxyl group distinguishes 20-HETE from other arachidonic acid metabolites and is crucial for its physiological and pathophysiological functions.