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Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

CNS-Penetrant Compound Library

Catalog No. L5900
  Library Compound List   Excel SDF

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 516 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
Get quote

Product Description

  • A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L5900)

Library Composition

Autophagy (108)
Apoptosis (86)
5-HT Receptor (54)
Dopamine Receptor (42)
Antibacterial (42)
Antibiotic (38)
Endogenous Metabolite (34)
AChR (32)
HIV Protease (27)
Adrenergic Receptor (26)
COX (24)
Sodium Channel (23)
Histamine Receptor (21)
GABA Receptor (20)
Mitophagy (18)
Calcium Channel (16)
Serotonin Transporter (14)
EGFR (14)
DNA/RNA Synthesis (14)
Potassium Channel (13)
iGluR (12)
Reactive Oxygen Species (11)
VEGFR (11)
Reverse Transcriptase (11)
PI3K (11)
Ferroptosis (11)
c-Kit (11)
NF-κB (11)
Norepinephrine (11)
Antifungal (10)
Parasite (10)
HDAC (10)
GluR (9)
Influenza Virus (9)
CDK (9)
PDGFR (9)
Estrogen/progestogen Receptor (8)
FLT (8)
mTOR (8)
AChE (8)
NMDAR (7)
Dehydrogenase (7)
MEK (7)
Beta Amyloid (7)
Bcr-Abl (7)
Antifection (6)
DNA Alkylator/Crosslinker (6)
SARS-CoV (6)
P-gp (6)
PDE (6)
Nucleoside Antimetabolite/Analog (6)
TNF (6)
Virus Protease (6)
Topoisomerase (6)
TRP/TRPV Channel (6)
Raf (6)
c-Fms (6)
NOD-like Receptor (NLR) (5)
LPL Receptor (5)
P450 (5)
Estrogen Receptor/ERR (5)
CSF-1R (5)
Microtubule Associated (5)
Drug Metabolite (5)
Glucocorticoid Receptor (5)
Src (5)
Adenosine Receptor (5)
Monoamine Oxidase (5)
S1P Receptor (5)
MMP (4)
FGFR (4)
HSV (4)
p38 MAPK (4)
MAO (4)
LRRK2 (4)
Transferase (4)
Antifolate (4)
DNA Alkylation (4)
PPAR (4)
ERK (4)
IL Receptor (3)
ABC (3)
Akt (3)
Interleukin (3)
HSP (3)
ATM/ATR (3)
HCV Protease (3)
Carbonic Anhydrase (3)
Phospholipase (3)
ALK (3)
PARP (3)
Tyrosine Kinases (3)
Proton pump (3)
Epigenetic Reader Domain (3)
Neurokinin receptor (3)
Opioid Receptor (3)
TGF-beta/Smad (3)
CaMK (3)
Proteasome (2)
Prostaglandin Receptor (2)
PAK (2)
Progesterone Receptor (2)
NOS (2)
OX Receptor (2)
advanced glycation end products (2)
NOD (2)
Phosphatase (2)
Melatonin Receptor (2)
MRP (2)
Monoamine Transporter (2)
Aryl Hydrocarbon Receptor (2)
Hedgehog/Smoothened (2)
PD-1/PD-L1 (2)
GPR (2)
CAT (2)
Decarboxylase (2)
DHFR (2)
STAT (2)
DNA-PK (2)
Sirtuin (2)
AMPK (2)
Trk receptor (2)
FAAH (2)
IκB/IKK (2)
Cannabinoid Receptor (2)
Gamma-secretase (2)
S6 Kinase (2)
BTK (2)
CRISPR/Cas9 (2)
HBV (2)
ROS (2)
HIF/HIF Prolyl-Hydroxylase (2)
Histone Acetyltransferase (2)
ROR (2)
BCL (2)
ROCK (2)
RIP kinase (2)
HMG-CoA Reductase (2)
Retinoid Receptor (2)
Vasopressin Receptor (2)
RAAS (2)
Isocitrate Dehydrogenase (IDH) (2)
CFTR (2)
Tyrosinase (1)
Pyroptosis (1)
Telomerase (1)
PDK (1)
Syk (1)
Sigma receptor (1)
Acyltransferase (1)
RSV (1)
PKC (1)
Adenosine deaminase (1)
Ras (1)
SGK (1)
LDL (1)
P2X Receptor (1)
Complement System (1)
Glutathione Peroxidase (1)
Free radical scavengers (1)
Fatty Acid Synthase (1)
Epoxide Hydrolase (1)
Annexin A (1)
E1/E2/E3 Enzyme (1)
DUB (1)
DNA Methyltransferase (1)
Cysteine Protease (1)
c-Met/HGFR (1)
GSK-3 (1)
Chloride channel (1)
Chk (1)
CCR (1)
Caspase (1)
Antiviral (1)
Beta-Secretase (1)
BCRP (1)
BACE (1)
Aromatase (1)
Aurora Kinase (1)
GlyT (1)
GST (1)
Nrf2 (1)
Lipase (1)
NADPH (1)
MT Receptor (1)
MLK (1)
Mitochondrial Metabolism (1)
Mdm2 (1)
MAPK (1)
Liver X Receptor (1)
Lipoxygenase (1)
Lipid (1)
JNK (1)
HIF (1)
JAK (1)
IRE1 (1)
Integrin (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
IGF-1R (1)
Hydroxylase (1)
Hydrogenase (1)
AhR (1)
Histone Methyltransferase (1)
Histone Demethylase (1)
Wnt/beta-catenin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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