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Compound LibrariesFocused Bioactive Libraries-Research FieldCharacteristic Bioactive Libraries-Neurological disordersCNS-Penetrant Compound Library
TOPProduct DescriptionPackaging & StorageSupporting FilesLibrary CustomizationLibrary Composition
TargetMol | Compound Library

CNS-Penetrant Compound Library

Catalog No. L5900

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 509 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5900

CNS-Penetrant Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 509 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files | TargetMol Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (60.2 MB)

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Autophagy
Apoptosis
5-HT Receptor
Dopamine Receptor
Antibacterial
Antibiotic
AChR
Endogenous Metabolite
HIV Protease
Adrenergic Receptor
COX
Sodium Channel
Histamine Receptor
Mitophagy
GABA Receptor
Calcium Channel
Serotonin Transporter
EGFR
DNA/RNA Synthesis
iGluR
Potassium Channel
PI3K
VEGFR
Norepinephrine
Reverse Transcriptase
NF-κB
c-Kit
Ferroptosis
Antifungal
Parasite
HDAC
CDK
Reactive Oxygen Species
PDGFR
GluR
AChE
mTOR
Influenza Virus
FLT
Estrogen/progestogen Receptor
Dehydrogenase
Bcr-Abl
Beta Amyloid
MEK
DNA Alkylator/Crosslinker
Virus Protease
Nucleoside Antimetabolite/Analog
TRP/TRPV Channel
Topoisomerase
PDE
Raf
NMDAR
Antifection
P-gp
SARS-CoV
c-Fms
Monoamine Oxidase
Src
LPL Receptor
Adenosine Receptor
MAO
CSF-1R
Glucocorticoid Receptor
P450
TNF
Microtubule Associated
NOD-like Receptor (NLR)
S1P Receptor
Transferase
p38 MAPK
Estrogen Receptor/ERR
Antifolate
ERK
Drug Metabolite
DNA Alkylation
HSV
MMP
LRRK2
FGFR
Proton pump
Carbonic Anhydrase
HCV Protease
ABC
Tyrosine Kinases
PPAR
PARP
Molecular Glues
Opioid Receptor
IL Receptor
Epigenetic Reader Domain
CaMK
Interleukin
TGF-beta/Smad
ALK
ATM/ATR
Ligand for E3 Ligase
Phospholipase
Neurokinin receptor
Proteasome
advanced glycation end products
NOS
CAT
DHFR
ROR
Histone Methyltransferase
DNA-PK
Ligands for Target Protein for PROTAC
RAAS
Phosphatase
Progesterone Receptor
Melatonin Receptor
MRP
HBV
ROCK
Aryl Hydrocarbon Receptor
RIP kinase
Gamma-secretase
Mitochondrial Metabolism
BTK
Monoamine Transporter
Isocitrate Dehydrogenase (IDH)
BCL
PAK
Hedgehog/Smoothened
FAAH
Vasopressin Receptor
OX Receptor
Akt
HSP
Prostaglandin Receptor
Trk receptor
Sirtuin
Decarboxylase
IκB/IKK
Retinoid Receptor
STAT
CRISPR/Cas9
GPR
AMPK
NOD
HMG-CoA Reductase
S6 Kinase
HIF/HIF Prolyl-Hydroxylase
CFTR
PD-1/PD-L1
Mdm2
Hydrogenase
Integrin
c-Met/HGFR
Antioxidant
BACE
Arrestin
NADPH
Histone Demethylase
Lipase
JNK
Glutathione Peroxidase
GSK-3
Wnt/beta-catenin
Cysteine Protease
Liver X Receptor
Caspase
PKC
IRE1
Annexin A
E1/E2/E3 Enzyme
LDL
MT Receptor
P2X Receptor
GlyT
ROS
Fatty Acid Synthase
JAK
CCR
Chk
Epoxide Hydrolase
Aurora Kinase
Lipoxygenase
IGF-1R
DUB
Indoleamine 2,3-Dioxygenase (IDO)
Telomerase
Lipid
BCRP
Beta-Secretase
MAPK
Antiviral
Free radical scavengers
Histone Acetyltransferase
Nrf2
Pyroptosis
RSV
GST
Aromatase
PDK
Hydroxylase
Adenosine deaminase
HIF
SGK
Complement System
Cannabinoid Receptor
Syk
DNA Methyltransferase
Ras
Sigma receptor
Tyrosinase
AhR
MLK

Keywords

CNS Penetrant Compound LibraryCNSPenetrant Compound Library
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