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TOPProduct DescriptionPackaging & StorageSupporting FilesLibrary CustomizationLibrary Composition
TargetMol | Compound Library

CNS-Penetrant Compound Library

Catalog No. L5900

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 660 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5900

CNS-Penetrant Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 660 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files | TargetMol Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (60.2 MB)

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

5-HT Receptor
Dopamine Receptor
Autophagy
Antibacterial
Antibiotic
Apoptosis
Endogenous Metabolite
AChR
Adrenergic Receptor
Histamine Receptor
Glucocorticoid Receptor
GABA Receptor
Calcium Channel
COX
Serotonin Transporter
Potassium Channel
Sodium Channel
Monoamine Oxidase
MAO
Parasite
DNA/RNA Synthesis
HIV Protease
GluR
AChE
iGluR
Norepinephrine
Antifungal
NMDAR
P450
Mitophagy
PDE
Reactive Oxygen Species
Nucleoside Antimetabolite/Analog
Beta Amyloid
HDAC
NF-κB
Carbonic Anhydrase
ADC Cytotoxin
Ferroptosis
Adenosine Receptor
VEGFR
Topoisomerase
Antifection
HSV
Influenza Virus
Reverse Transcriptase
Dehydrogenase
DNA Alkylator/Crosslinker
PDGFR
DNA Alkylation
P-gp
Prostaglandin Receptor
Transferase
PI3K
Virus Protease
TRP/TRPV Channel
Opioid Receptor
Interleukin
EGFR
AMPK
MEK
Neurokinin receptor
c-Kit
HMG-CoA Reductase
Proteasome
DHFR
Src
HCV Protease
Amino Acids and Derivatives
Estrogen/progestogen Receptor
Antioxidant
Phosphatase
MRP
PPAR
PARP
Antifolate
Annexin A
Gamma-secretase
CDK
Mitochondrial Metabolism
ROS
MMP
Epigenetic Reader Domain
CaMK
mTOR
SARS-CoV
GPR
Phospholipase
Hydroxylase
FGFR
FLT
HIF/HIF Prolyl-Hydroxylase
DNA-PK
Histone Methyltransferase
p38 MAPK
c-Met/HGFR
Histone Demethylase
NADPH
Lipase
RAAS
JNK
GSK-3
Tyrosine Kinases
Cysteine Protease
Vitamin
Caspase
PKC
ROCK
ERK
CSF-1R
Raf
MT Receptor
BTK
Smo
BCL
IL Receptor
Aurora Kinase
HSP
LRRK2
Retinoid Receptor
STAT
ribosome
Adenosine deaminase
TNF
Cannabinoid Receptor
Sigma receptor
Microtubule Associated
NOD-like Receptor (NLR)
Imidazoline Receptor
HER
Melanin-concentrating Hormone Receptor (MCHR)
Thyroid hormone receptor(THR)
advanced glycation end products
Chloride channel
ATPase
Proton pump
NOS
CAT
Hydrogenase
MALT
Arginase
Reductase
BACE
Arrestin
Cell wall
Glutathione Peroxidase
Progesterone Receptor
Melatonin Receptor
ABC
PKA
Estrogen Receptor/ERR
Wnt/beta-catenin
Rho
Serine/threonin kinase
Liver X Receptor
Neurotensin Receptor
Immunology/Inflammation related
IDO
IRE1
UGT
Bcr-Abl
Drug Metabolite
P2X Receptor
GlyT
Monoamine Transporter
Molecular Glues
Isocitrate Dehydrogenase (IDH)
MAGL
Fatty Acid Synthase
JAK
FAAH
Endothelin Receptor
OX Receptor
Xanthine Oxidase
Epoxide Hydrolase
Lipoxygenase
IGF-1R
DNA
Indoleamine 2,3-Dioxygenase (IDO)
Telomerase
Lipid
BCRP
Akt
Beta-Secretase
PGE Synthase
Acyltransferase
Antiviral
TLR
Trk receptor
Free radical scavengers
Histone Acetyltransferase
Nrf2
Pyroptosis
IκB/IKK
Neprilysin
GST
ATM/ATR
c-Fms
Ligand for E3 Ligase
Aromatase
CRISPR/Cas9
HIF
RXFP receptor
c-RET
SGK
Complement System
Platelet aggregation
Syk
Anti-infection
DNA Methyltransferase
NOD
S6 Kinase
Ras
TAM Receptor
Thrombin
FAK
AhR
CFTR
MLK
PD-1/PD-L1
NO Synthase

Keywords

CNS Penetrant Compound LibraryCNSPenetrant Compound Library
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