Deuterium Labeled Compounds

JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.

Donafenib (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).

VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.

5-Hydroxy-L-tryptophan-4,6,7-d3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.

DL-Metanephrine-d3 Hydrochloride is L-Metanephrine labeled with deuterium atoms and can be used to study the metabolic flow of L-Metanephrine in the body.

Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) is the deuterium substitute of Ursodeoxycholic acid, and is an internal standard for the quantitative determination of Ursodeoxycholic Acid (UDCA) levels by LC MS or GC MS.

Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.

L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].

Corticosterone-d8 is a 2H-labeled corticosteroid, an orally active adrenal corticosteroid with mineralocorticoid and glucocorticoid activity, involved in hormonal regulation in animals.

Choline-d4 Chloride (Choline-1,1,2,2-D4 Chloride) is a deuterated form of Choline chloride, an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.

Dimethyl-d6 Sulfoxide is a form in which hydrogen ( H ) of dimethyl sulfoxide (DMSO, (CH3) 2S = O) is replaced by another isotope deuterium ( d ). Dimethyl-d6 Sulfoxide is a common solvent in nuclear magnetic resonance spectroscopy.

Vancomycin-C13,D3 is a compound labeled with 13C and 2H. Vancomycin is a glycopeptide antibiotic that exerts antibacterial activity by altering cell membrane permeability and selectively inhibiting RNA synthesis.

Pivalic acid-d9 (Trimethyl-d9-acetic acid) is a 2H-labeled version of Pivalic acid, used for synthesizing neopentyl chloride and neopentyl esters.

Crisaborole-d4 (AN-2728-d4) is a 2H-labeled version of Crisaborole. Crisaborole is a phosphodiesterase 4 (PDE4) inhibitor and cytokine release inhibitor, used in the study of atopic dermatitis.

Zanubrutinib-d5 (BGB-3111-d5), a deuterium-labeled Zanubrutinib, is an orally available Bruton's tyrosine kinase inhibitor for the study of B-cell malignancies.

Androstenedione-d7 is a deuterated compound of the steroid hormone Androstenedione, and is used to study the metabolism of Androstenedione.

Cholesterol-d6 is a deuterated chlosterol that can be used to study lipid membrane flow and chlosterol metabolism in vivo.

Ezetimibe phenoxy glucuronide-d4 (Ezetimibe glucuronide-d4) is a 2H-labeled Ezetimibe phenoxy glucuronide, an active metabolite of Ezetimibe that lowers cholesterol by inhibiting cholesterol absorption in the intestine, thus reducing LDL-C.

Erythromycin-13C-d3 is a 13C- and deuterated erythromycin that can be used to study the metabolic pathways of erythromycin in vivo.

3-Methoxy Dopamine-d4 Hydrochloride (3-O-methyl Dopamine-d4 hydrochloride) is a deuterated methoxytyramine hydrochloride.

Spermidine-d6 is a deuterated form of Spermidine. Spermidine is a natural polyamine present in ribosomes and living tissues, with functions in inflammation reduction, lipid metabolism regulation, and modulation of cell growth and death.

Zilpaterol-d7 (trans-(±)-Zilpaterol-d7) is a 2H-labeled Zilpaterol. Zilpaterol is a β-adrenergic receptor agonist, reducing marbling score by increasing muscle cross-sectional area and diluting intramuscular fat in beef cattle.

Ampicillin-d5 is a 2H-labeled Ampicillin. Ampicillin is a β-lactam antibiotic, a semi-synthetic penicillin with bactericidal activity against both gram-positive and gram-negative bacteria.

Clencyclohexerol-d10 is a deuterated Clencyclohexerol and is an isotopic marker for lencyclohexerol. Clencyclohexerol-d10 is a β-agonist and growth promoter in animals.

Imatinib-d8 (STI571 D8) is a 2H-labeled version of Imatinib. Imatinib is a multi-target receptor tyrosine kinase inhibitor with anti-tumor activity, selectively inhibiting BCR-ABL, v-Abl, PDGFR, c-kit kinases, and is used in chronic myeloid leukemia treatment.

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker that is used in the study of cardiovascular disease.

Albendazole-d3, a deuterated compound of Albendazole, is an anthelmintic and can be used to study the metabolism of Albendazole in vivo.

N,N'-Dimethylarginine-d6 (SDMA-d6) is a 2H-labeled N,N'-Dimethylarginine, a 202-Da methylated analog of the amino acid arginine, formed during post-translational methylation by methyltransferases.

Busulfan-d8 (Sulphabutin-d8) is a deuterated Busulfan. Busulfan is an effective alkylating anticancer agent with immunosuppressive and myeloablative activities. It exerts anti-cancer activity by crosslinking DNA and causing DNA damage.

L-Carnitine-d3 Chloride ((R)-Carnitine-d3 hydrochloride) is the deuterated form of L-Carnitine hydrochloride, used as an internal standard for detecting total carnitine in raw materials. L-Carnitine (L(-)-Carnitine) is an endogenous human molecule involved in fatty acid metabolism.

Cimbuterol-d9 is deuterium-labeled Cimbuterol, a 12 β(2)-adrenergic agonist.

Homovanillic acid-d5 (Vanilacetic acid-d5) is a deuterated Homovanillic acid, which can be used to study the metabolism of Homovanillic acid in vivo. Homovanillic acid is a dopamine metabolite, which is an indicator of central dopamine function in primates. Homovanillic acid is a dopamine metabolite and an indicator of central dopamine function in primates.

Norverapamil-d7 HCl is a deuterated compound of Norverapamil HCl. Norverapamil HCl has a CAS number of 67812-42-4. Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

Rac-Propranolol-d7 is a 2H-labeled Rac-Propranolol. Propranolol is an effective β-adrenergic receptor (βAR) antagonist that inhibits β1AR and β2AR, used in cardiovascular and metabolic disease research.

Apalutamide-13C-d3 (RN-509-13C,d3) is a 13C and 2H-labeled version of Apalutamide. Apalutamide is an efficient androgen receptor (AR) antagonist used in the study of prostate diseases.

Tiapride-d3 is a deuterated form of Tiapride, a selective dopamine D2 receptor antagonist and an antipsychotic compound.

Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11 16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.

Trilostane-d3 is a deuterated compound of Trilostane. Trilostane has a CAS number of 13647-35-3. Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.

Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.

Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.

DINP-d4 is a deuterated compound of DINP.

ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).

1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.

Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer). It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric aci......

Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and HIF-2α in Hep3B hepatocellular carcinoma cells. It increases levels of secreted erythropoietin in Hep3B cells in a concentration-dependent manner and increases erythropoiesis in rats when administered at doses of 25 and 50 mg/kg. Roxadustat reverses anemia in a rat model of chronic inflammation induced by peptidoglycan-polysaccharide, as well as a rat model of chronic kidney disease induced by 5/6 nephrectomy. It reduces tumor growth and increases survival in a murine Lewis lung carcin......