Deuterium Labeled Compounds

JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.

Donafenib (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).

VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.

Corticosterone-d8 is a 2H-labeled corticosteroid, an orally active adrenal corticosteroid with mineralocorticoid and glucocorticoid activity, involved in hormonal regulation in animals.

5-Hydroxy-L-tryptophan-4,6,7-d3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.

Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.

DL-Metanephrine-d3 Hydrochloride is L-Metanephrine labeled with deuterium atoms and can be used to study the metabolic flow of L-Metanephrine in the body.

Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) is the deuterium substitute of Ursodeoxycholic acid, and is an internal standard for the quantitative determination of Ursodeoxycholic Acid (UDCA) levels by LC MS or GC MS.

L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].

Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11 16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.

Choline-d4 Chloride (Choline-1,1,2,2-D4 Chloride) is a deuterated form of Choline chloride, an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.

Dimethyl-d6 Sulfoxide is a form in which hydrogen ( H ) of dimethyl sulfoxide (DMSO, (CH3) 2S = O) is replaced by another isotope deuterium ( d ). Dimethyl-d6 Sulfoxide is a common solvent in nuclear magnetic resonance spectroscopy.

Zanubrutinib-d5 (BGB-3111-d5), a deuterium-labeled Zanubrutinib, is an orally available Bruton's tyrosine kinase inhibitor for the study of B-cell malignancies.

Vancomycin-C13,D3 is a compound labeled with 13C and 2H. Vancomycin is a glycopeptide antibiotic that exerts antibacterial activity by altering cell membrane permeability and selectively inhibiting RNA synthesis.

Pivalic acid-d9 (Trimethyl-d9-acetic acid) is a 2H-labeled version of Pivalic acid, used for synthesizing neopentyl chloride and neopentyl esters.

Crisaborole-d4 (AN-2728-d4) is a 2H-labeled version of Crisaborole. Crisaborole is a phosphodiesterase 4 (PDE4) inhibitor and cytokine release inhibitor, used in the study of atopic dermatitis.

Apalutamide-13C-d3 (RN-509-13C,d3) is a 13C and 2H-labeled version of Apalutamide. Apalutamide is an efficient androgen receptor (AR) antagonist used in the study of prostate diseases.

Trilostane-d3 is a deuterium-substituted isotope-labeled compound of Trilostane, which is used primarily as a quantitative tracer.Trilostane is a competitive and specific inhibitor of 3-beta-hydroxysteroid dehydrogenase (3β-HSD), with the advantage of oral activity.Trilostane reduces the synthesis of steroid hormones by inhibiting the activity of 3β-HSD, and can be Used in studies of Cushing's syndrome (hypercortisolism), Con's syndrome (hyperaldosteronism), and postmenopausal breast cancer.

Androstenedione-d7 is a deuterated compound of the steroid hormone Androstenedione, and is used to study the metabolism of Androstenedione.

Cholesterol-d6 is a deuterated chlosterol that can be used to study lipid membrane flow and chlosterol metabolism in vivo.

Ezetimibe phenoxy glucuronide-d4 (Ezetimibe glucuronide-d4) is a 2H-labeled Ezetimibe phenoxy glucuronide, an active metabolite of Ezetimibe that lowers cholesterol by inhibiting cholesterol absorption in the intestine, thus reducing LDL-C.

Erythromycin-13C-d3 is a 13C- and deuterated erythromycin that can be used to study the metabolic pathways of erythromycin in vivo.

3-Methoxy Dopamine-d4 Hydrochloride (3-O-methyl Dopamine-d4 hydrochloride) is a deuterated methoxytyramine hydrochloride.

Spermidine-d6 is a deuterated form of Spermidine. Spermidine is a natural polyamine present in ribosomes and living tissues, with functions in inflammation reduction, lipid metabolism regulation, and modulation of cell growth and death.

Zilpaterol-d7 (trans-(±)-Zilpaterol-d7) is a 2H-labeled Zilpaterol. Zilpaterol is a β-adrenergic receptor agonist, reducing marbling score by increasing muscle cross-sectional area and diluting intramuscular fat in beef cattle.

3-Indoleacrylic acid-d4 is a deuterated marker of 3-Indoleacrylic acid used as a tracer for labeled site tracking.3-Indoleacrylic acid is a tryptophan metabolite produced by Streptococcus spp. It possesses highly potent antialgae activity and is capable of increasing reactive oxygen species (ROS) production and inhibiting nutrient assimilation genes.

Ampicillin-d5 is a 2H-labeled Ampicillin. Ampicillin is a β-lactam antibiotic, a semi-synthetic penicillin with bactericidal activity against both gram-positive and gram-negative bacteria.

Clencyclohexerol-d10 is a deuterated Clencyclohexerol and is an isotopic marker for lencyclohexerol. Clencyclohexerol-d10 is a β-agonist and growth promoter in animals.

Imatinib-d8 (STI571 D8) is a 2H-labeled version of Imatinib. Imatinib is a multi-target receptor tyrosine kinase inhibitor with anti-tumor activity, selectively inhibiting BCR-ABL, v-Abl, PDGFR, c-kit kinases, and is used in chronic myeloid leukemia treatment.

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker that is used in the study of cardiovascular disease.

Albendazole-d3, a deuterated compound of Albendazole, is an anthelmintic and can be used to study the metabolism of Albendazole in vivo.

Norverapamil-d7 HCl (D591-d7 HCl) is a 2H-labeled Norverapamil HCl, a calcium channel blocker and P-glycoprotein (P-gp) inhibitor, used in cardiovascular and neurodegenerative disease research.

N,N'-Dimethylarginine-d6 (SDMA-d6) is a 2H-labeled N,N'-Dimethylarginine, a 202-Da methylated analog of the amino acid arginine, formed during post-translational methylation by methyltransferases.

Busulfan-d8 (Sulphabutin-d8) is a deuterated Busulfan. Busulfan is an effective alkylating anticancer agent with immunosuppressive and myeloablative activities. It exerts anti-cancer activity by crosslinking DNA and causing DNA damage.

L-Carnitine-d3 Chloride ((R)-Carnitine-d3 hydrochloride) is the deuterated form of L-Carnitine hydrochloride, used as an internal standard for detecting total carnitine in raw materials. L-Carnitine (L(-)-Carnitine) is an endogenous human molecule involved in fatty acid metabolism.

Cimbuterol-d9 is deuterium-labeled Cimbuterol, a 12 β(2)-adrenergic agonist.

Homovanillic acid-d5 (Vanilacetic acid-d5) is a deuterated Homovanillic acid, which can be used to study the metabolism of Homovanillic acid in vivo. Homovanillic acid is a dopamine metabolite, which is an indicator of central dopamine function in primates. Homovanillic acid is a dopamine metabolite and an indicator of central dopamine function in primates.

Rac-Propranolol-d7 is a 2H-labeled Rac-Propranolol. Propranolol is an effective β-adrenergic receptor (βAR) antagonist that inhibits β1AR and β2AR, used in cardiovascular and metabolic disease research.

Furosemide-d5 is a deuterated compound of Furosemide.

Metronidazole-d4 is a deuterated compound of Metronidazole.

Tiapride-d3 is a deuterated form of Tiapride, a selective dopamine D2 receptor antagonist and an antipsychotic compound.

Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.

Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.

DINP-d4 is a deuterated compound of DINP.

ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).

Succinic acid-d6 is a useful organic compound for research related to life sciences and the catalog number is T64570.