RXFP receptor

AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

RXFP3 4 agonist 2 is a potent, non-peptidic bis-RXFP3 4 agonist that facilitates the interaction between RXFP3 and β-arrestin-2 and is useful for studying diseases caused by metabolic abnormalities.

RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1 2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3 I5 in rats.RLX-33 can be used to study the metabolic syndrome.

B7-33 is a single-chain relaxin analog and a selective agonist for relaxin receptor 1 (RXFP1). It binds to RXFP1 and preferentially activates the pERK pathway in cells expressing RXFP1, rather than cAMP. B7-33 serves as an antifibrotic agent and provides cardioprotective effects.

ML-290 is an effective relaxin insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.