Natural Product Derivatives Library

Name: Natural Product Derivatives Library
Brand: TargetMol
SKU: NY1000

Catalog No. NY1000

Historically, natural products have been pharma's treasure trove. According to the Natural Products Library Initiative at the Scripps Research Institute, "from 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (530/0) being either natural products or derived there from. “In a sense, this is not surprising. In nature, after all, creatures — and at the more basic level, structures, such as receptors and their ligands — have been co—evolving for billions of years.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. NY1000

Natural Product Derivatives Library

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30 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)

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Product Description

The library consists of more than 3745 members belonging 22 scaffolds (average 180 compounds per scaffold).
The library includes the following sub-libraries:
Cytisine-based sub-library
Matrine-based sub-library
Podophyllotoxin-based sub-library
Sub-library based on naturally occurring privileged BBS such ashydroxy-prolines, triptamine, nor-tropolone etc.
TargetMol "Beyond RO5" filters have been applied for the library population (See Phys-chem parameters for the library members).
NO Med-Chem restrictions (widely accepted and proprietary TargetMol substructure filters on reactive functionalities, toxicophoric, instability suspicions etc.).
More than 90% purity for each library member confirmed by LC-MS or NMR analysis.