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Chromatin/Epigenetic
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Chromatin/EpigeneticPKC
Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
- Phorbol 12-myristate 13-acetateTQ019816561-29-8Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.
- $40
- $50
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Cited - HypericinT6S0923548-04-91. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
- $52
SizeQTY - StaurosporineT668062996-74-1Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
- $56
SizeQTY Cited - Hypocrellin AT577177029-83-5Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.
- $47
SizeQTY - α-Vitamin ET164859-02-9α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
- $38
SizeQTY Cited - Methyl-HesperidinT022811013-97-1Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
- $50
SizeQTY - MyricitrinT275717912-87-7Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
- $50
SizeQTY Cited - 20-HETET1402179551-86-3In house20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway to increase FBXO10 expression.20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway.
- $498
SizeQTY Cited - TV 3279T77332209394-29-6In houseTV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
- $195
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- A-674563 2HCl(552325-73-2(fb-2hcl))T6139LA-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
- $78
SizeQTY - [Ala107]-MBP (104-118) acetateTP1887L1[Ala107]-MBP (104-118) acetate ([Ala107]-MBP ) is synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).
- $297
SizeQTY - [Ala113]-MBP (104-118) acetateTP1888L1[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 28-62 μM.
- $297
SizeQTY - Delcasertib acetateT11740LDelcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Inquiry
- PKC-theta inhibitor hclT58172253640-49-0PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).
- $85
SizeQTY - ConiferaldehydeTN369420649-42-7Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1).
- $299
SizeQTY - A-674563 HCl (552325-73-2(free base))T44442070009-66-2A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in th
- $77
SizeQTY - HBDDET39030154675-18-0In houseHBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells.
- $350
SizeQTY - FasudilT1606103745-39-7Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
- $33
SizeQTY - PKCiota-IN-2T98632230055-52-2PKCiota-IN-2 (PKCiota-IN-49) is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively
- $117
SizeQTY - Protein Kinase C 19-31 acetateTP1053LProtein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate
- $51
SizeQTY - DelcasertibT11740949100-39-4Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).
- $213
SizeQTY - Safingol hydrochlorideT83978139755-79-6In houseSafingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k.
- $195
SizeQTY - Gardenin ATN411421187-73-5Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
- $197
SizeQTY - HA-1004 dihydrochlorideT868192564-34-6HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
- $370
SizeQTY - ZIP acetate(863987-12-6 free base)TP1924L1ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-ph
- $133
SizeQTY - Pep2m, myristoylated acetateTP1945L1Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates A
- $159
SizeQTY - N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamineT92561071135-06-2N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor[1].
- $148
SizeQTY - PKC β pseudosubstrate acetateTP1955LPKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.
- $292
SizeQTY - PKCε Inhibitor Peptide acetateT35827LPKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC.
- $98
SizeQTY - PKC ζ pseudosubstrate acetateTP1956LPKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antenna
- $133
SizeQTY - Malantide acetate(86555-35-3 free base)TP1789LMalantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activity in vitro.
- $78
SizeQTY - DCPLA-MET1098056687-67-3In houseDCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator.
- $79
SizeQTY - CRT0066854 hydrochlorideT108882250019-91-9In houseCRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
- $33
SizeQTY - Y06137T133632226534-49-0In houseY06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-resistant prostate cancer.
- $55
SizeQTY - Ionomycin calciumT1166556092-82-1In houselonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis.
- $127
SizeQTY Cited - NSC668394T28212382605-72-3In houseNSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.
- $69
SizeQTY - ML-7 hydrochlorideT3050110448-33-4ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.
- $42
SizeQTY Cited - TPPBT17148497259-23-1TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
- $163
SizeQTY Cited - AfuresertibT19111047644-62-1Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
- $33
SizeQTY Cited - Fasudil hydrochlorideT3060105628-07-7Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
- $35
SizeQTY Cited - Go 6983T6313133053-19-7Go 6983 is a pan-PKC inhibitor targeting PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, exhibiting IC50 values of 7 nM, 7 nM, 6 nM, 10 nM, and 60 nM, respectively.
- $36
SizeQTY Cited - GSK-690693T6285937174-76-0GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
- $41
SizeQTY Cited - Ro 31-8220 MesylateT6643138489-18-6Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.
- $44
SizeQTY Cited - Ro-3306T2356872573-93-8RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
- $32
SizeQTY Cited - PiceatannolT061010083-24-6Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
- $39
SizeQTY Cited - PsychosineT212602238-90-6Psychosine (Galactosylsphingosine) is a PKC inhibitor, a substrate for the enzyme galactosylceramide cerebrosidase (GALC), and a potential biomarker of Krabbe's disease.Psychosine is highly cytotoxic and induces cell death in a variety of cells.
- $535
SizeQTY - Bisindolylmaleimide VIII acetateT10549138516-31-1Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
- $39
SizeQTY - Cimiside ETN3655154822-57-8Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen
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