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TV 3279
🥰Excellent
Catalog No. T77332Cas No. 209394-29-6
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
TV 3279
🥰Excellent
Purity: 97%
Catalog No. T77332Cas No. 209394-29-6
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $389 | In Stock | |
| 25 mg | $592 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $247 | In Stock |
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Purity:97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells. |
| In vivo | Chronic TV3279 (26 mg kg-1 for 21 days; rats) similarly inhibited ∼50% of striatal ChE activity but did not affect MAO activity or amine levels. Accordingly, chronic TV3279 abolished the ability of TCP to initiate L-dopa-induced hyperactivity. In contrast, chronic as well as acute treatments with TV3279 reduced spontaneous motor activity.[2] |
| Molecular Weight | 272.34 |
| Formula | C16H20N2O2 |
| Cas No. | 209394-29-6 |
| Smiles | N(CC#C)[C@@H]1C=2C(CC1)=CC=C(OC(N(CC)C)=O)C2 |
| Relative Density. | 1.14 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.73 mg/mL (10.01 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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