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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $440 | In Stock | |
10 mg | $648 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,390 | In Stock | |
100 mg | $1,870 | In Stock | |
500 mg | $3,730 | In Stock | |
1 mL x 10 mM (in DMSO) | $411 | In Stock |
Description | TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells. |
In vivo | Chronic TV3279 (26 mg kg-1 for 21 days; rats) similarly inhibited ∼50% of striatal ChE activity but did not affect MAO activity or amine levels. Accordingly, chronic TV3279 abolished the ability of TCP to initiate L-dopa-induced hyperactivity. In contrast, chronic as well as acute treatments with TV3279 reduced spontaneous motor activity.[2] |
Molecular Weight | 272.34 |
Formula | C16H20N2O2 |
Cas No. | 209394-29-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 2.73 mg/mL (10.01 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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