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Wnt/Hedgehog/Notch Compound Library

Catalog No. L4300
  Library Compound List   Excel SDF

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. Constitutive activation of the Hh pathway leading to tumorigenesis is seen in basal cell carcinomas and medulloblastoma. A variety of other human cancers, including brain, gastrointestinal, lung, breast and prostate cancers, also demonstrate inappropriate activation of this pathway. Targeting the Hh signaling pathway provides a new and exciting therapeutic option for a broad variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. The Notch signaling cascade is critical for cell proliferation, differentiation, development and homeostasis. Deregulated Notch signaling is found in various diseases, such as T-cell leukemia, breast cancer, prostate cancer, colorectal cancer and lung cancer as well as central nervous system (CNS) malignancies, CADASIL, Alagille syndrome, spondylocostal dysostosis, etc.

Wnt/Hedgehog/Notch Compound Library from TargetMol, a unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds, can be used for research in Wnt/Hedgehog/Notch signaling and related drug screening (high throughput and high content screening).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L4300)

Library Composition

Wnt/beta-catenin (49)
GSK-3 (40)
Casein Kinase (23)
Hedgehog/Smoothened (21)
CDK (18)
Gamma-secretase (15)
c-Myc (13)
ROCK (11)
CaMK (9)
PKC (6)
PKA (6)
PPAR (6)
Src (5)
Phospholipase (4)
Porcupine (3)
Autophagy (3)
Aurora Kinase (3)
ATPase (3)
PI3K (3)
p38 MAPK (3)
Smo (3)
Immunology & Inflammation related (2)
STAT (2)
Sodium Channel (2)
S6 Kinase (2)
MEK (2)
MLK (2)
NF-κB (2)
FLT (2)
GABA Receptor (2)
HDAC (2)
cholecystokinin (2)
Estrogen/progestogen Receptor (2)
ERK (2)
Carbonic Anhydrase (2)
Beta Amyloid (2)
Epigenetic Reader Domain (2)
DNA Alkylation (2)
Arginase (1)
Chk (1)
Pim (1)
Bcr-Abl (1)
Potassium Channel (1)
BCL (1)
Raf (1)
FGFR (1)
S1P Receptor (1)
Apoptosis (1)
PDGFR (1)
Antiviral (1)
Antifungal (1)
Antibacterial (1)
ALK (1)
Syk (1)
TGF-beta/Smad (1)
TNF (1)
Tyrosine Kinases (1)
Serine/threonin kinase (1)
c-Met/HGFR (1)
PDE (1)
IGF-1R (1)
Glucocorticoid Receptor (1)
Glucokinase (1)
GluR (1)
GRK (1)
Akt (1)
DYRK (1)
Histamine Receptor (1)
Histone Methyltransferase (1)
HIV Protease (1)
DNA-PK (1)
P450 (1)
Influenza Virus (1)
JAK (1)
JNK (1)
LRRK2 (1)
DHFR (1)
MMP (1)
Dehydrogenase (1)
COX (1)
FAK (1)
ABC (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE