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Bryostatin 1
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein [Kis: 8.07 nM and 0.45 nM].
Catalog No. T14831Cas No. 83314-01-6
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Bryostatin 1
Catalog No. T14831Cas No. 83314-01-6
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein [Kis: 8.07 nM and 0.45 nM].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg | $593 | 35 days |
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| Description | Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein [Kis: 8.07 nM and 0.45 nM]. |
| In vitro | Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation. The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed [1]. Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via TLR4 through the MyD88-independent pathway which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4+ T-helper (Th) lymphocytes into Th2 versus Th1 effector cells [2]. |
| In vivo | Bryostatin 1 (30 μg/kg; i.p.; 3 days per week; for 2 weeks) treatment completely prevents the onset of EAE [2]. |
| Molecular Weight | 905.03 |
| Formula | C47H68O17 |
| Cas No. | 83314-01-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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