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Tenofovir
Catalog No. T1649Cas No. 147127-20-6
Alias TDF, PMPA, GS 1278
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
Tenofovir
Catalog No. T1649Alias TDF, PMPA, GS 1278Cas No. 147127-20-6
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $37 | In Stock | |
| 10 mg | $50 | In Stock | |
| 25 mg | $71 | In Stock | |
| 50 mg | $95 | In Stock | |
| 100 mg | $133 | In Stock | |
| 500 mg | $336 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock |
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Purity:99.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone. |
| In vitro | 4 μM Tenofovir completely inhibited the growth of HIVIIIB in MT-2 cells.Tenofovir inhibited hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir reduced the viral cytopathic effects of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) in MT-4 cells with EC50s of 1.15 μg/mL, 1.12 μg/mL, and 1.05 μg/mL.Tenofovir also reduced the viral cytopathic effects of SIV(mac251), SIV(B670), SHIV(89.6) and SHIV(89.6). Tenofovir also reduced the cytopathic effect of SIV(mac251),SIV(B670),SHIV(89.6) and SHIV(RTSHIV).Tenofovir showed unique activity against polynucleoside-resistant HIV expressing the Q151M mutation, and was less susceptible to viruses with the T69S insertion mutation. |
| In vivo | 4 μM Tenofovir completely inhibited the growth of HIVIIIB in MT-2 cells.Tenofovir inhibited hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir reduced the viral cytopathic effects of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) in MT-4 cells with EC50s of 1.15 μg/mL, 1.12 μg/mL, and 1.05 μg/mL.Tenofovir also reduced the viral cytopathic effects of SIV(mac251), SIV(B670), SHIV(89.6) and SHIV(89.6). Tenofovir also reduced the cytopathic effect of SIV(mac251),SIV(B670),SHIV(89.6) and SHIV(RTSHIV).Tenofovir showed unique activity against polynucleoside-resistant HIV expressing the Q151M mutation, and was less susceptible to viruses with the T69S insertion mutation. |
| Cell Research | Cells are plated into 48-well tissue culture plates (39,000 cells/mL) and allowed to grow for 48 h followed by treatment with vehicle or Tenofovir. Following the treatment period, cell viability is assessed using the MTT assay. The MTT assay relies on the conversion of tetrazolium dye 3-(4,5-dimethlthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to formazan by NAD(P)H-dependent oxidoreductases[1]. |
| Alias | TDF, PMPA, GS 1278 |
| Molecular Weight | 287.21 |
| Formula | C9H14N5O4P |
| Cas No. | 147127-20-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (13.92 mM), Heating is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 2 mg/mL (6.96 mM) | |||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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