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Approved Drug Library

Catalog No. L1000
  Library Compound List   Excel SDF

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

Approved drugs all have known and well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization. Hits from this set will provide a significant head start in any drug optimization program.

In addition, a growing number of compounds have been identified from this library that can functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a combination of several molecules.

We put the compounds that should be provided in the form of dry powder together to form Part B in order to ensure the best using effect of the compound library and increase the probability of successful screening as much as possible.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 2863 approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • All compounds collected in this library are drugs approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), etc;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas, such as Cancer, Cardiovascular disease, GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc.
  • More detailed compound information with structure, target, activity, IC50 value, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1000)

Library Composition

Antibacterial (418)
Antibiotic (397)
Autophagy (345)
Endogenous Metabolite (258)
Apoptosis (250)
Adrenergic Receptor (167)
5-HT Receptor (165)
AChR (145)
COX (118)
Dopamine Receptor (115)
Parasite (102)
Histamine Receptor (100)
Antifungal (86)
DNA/RNA Synthesis (86)
Sodium Channel (84)
HIV Protease (82)
Potassium Channel (76)
Calcium Channel (72)
Topoisomerase (52)
Glucocorticoid Receptor (52)
Estrogen/progestogen Receptor (50)
Ferroptosis (48)
PDE (46)
Influenza Virus (45)
P450 (43)
RAAS (40)
Reactive Oxygen Species (39)
GABA Receptor (39)
SARS-CoV (39)
NF-κB (35)
Dehydrogenase (33)
EGFR (33)
HCV Protease (31)
ribosome (31)
Mitophagy (31)
VEGFR (30)
AChE (30)
c-Kit (30)
Serotonin Transporter (29)
Nucleoside Antimetabolite/Analog (29)
PPAR (29)
PDGFR (28)
Microtubule Associated (27)
Reverse Transcriptase (26)
Norepinephrine (25)
Prostaglandin Receptor (25)
Estrogen Receptor/ERR (24)
Proteasome (24)
HSV (24)
Antifection (22)
Progesterone Receptor (22)
MAO (22)
ATPase (22)
HBV (21)
Opioid Receptor (21)
iGluR (20)
Proton pump (20)
DNA Alkylator/Crosslinker (20)
Thrombin (18)
HDAC (18)
Virus Protease (18)
Carbonic Anhydrase (18)
Monoamine Oxidase (17)
FLT (17)
Androgen Receptor (17)
TNF (16)
TRP/TRPV Channel (16)
FGFR (15)
c-Met/HGFR (15)
MRP (15)
ROS (15)
Adenosine Receptor (15)
GNRH Receptor (15)
JAK (15)
DPP-4 (14)
Bcr-Abl (14)
Tyrosine Kinases (14)
NMDAR (13)
Antifolate (13)
Src (13)
Phosphatase (13)
Thyroid hormone receptor(THR) (13)
Raf (12)
Drug Metabolite (12)
PKC (12)
Amino Acids and Derivatives (12)
CDK (12)
Retinoid Receptor (12)
Transferase (11)
IL Receptor (11)
DHFR (11)
HMG-CoA Reductase (11)
MMP (11)
Lipoxygenase (11)
GluR (11)
Phospholipase (11)
c-RET (10)
CaMK (10)
DNA gyrase (10)
PARP (10)
P2 Receptor (10)
P-gp (10)
ALK (10)
Mitochondrial Metabolism (10)
Factor Xa (10)
AMPK (9)
Vasopressin Receptor (9)
Interleukin (9)
DNA Alkylation (9)
NO Synthase (9)
STAT (8)
DNA (8)
ABC (8)
SGLT (8)
CAT (8)
HIF/HIF Prolyl-Hydroxylase (8)
Tyrosinase (8)
Chloride channel (8)
Serine Protease (7)
NADPH (7)
Neurokinin receptor (7)
ROCK (7)
Beta Amyloid (7)
MEK (7)
Guanylate cyclase (7)
GPR (7)
Antiviral (7)
PI3K (7)
HER (7)
CFTR (7)
Monoamine Transporter (6)
TAM Receptor (6)
BTK (6)
BCL (6)
Aromatase (6)
Glucagon Receptor (6)
mTOR (6)
ADC Cytotoxin (6)
Oxytocin Receptor (6)
Antioxidant (6)
PKA (6)
Glutathione Peroxidase (6)
Trk receptor (6)
S1P Receptor (6)
Sigma receptor (6)
Reductase (6)
Hedgehog/Smoothened (6)
HSP (5)
Integrin (5)
LPL Receptor (5)
Xanthine Oxidase (5)
Histone Methyltransferase (5)
Hydroxylase (5)
ERK (5)
Wnt/beta-catenin (5)
Caspase (5)
Fatty Acid Synthase (5)
Endothelin Receptor (5)
Anti-infection (5)
DNA Methyltransferase (5)
Cysteine Protease (5)
Cell wall (5)
FXR (4)
IκB/IKK (4)
GSK-3 (4)
Leukotriene Receptor (4)
Lipid (4)
Serine/threonin kinase (4)
Annexin A (4)
NOS (4)
Decarboxylase (4)
Histone Demethylase (4)
CaSR (4)
UGT (4)
Smo (4)
Neprilysin (4)
Melatonin Receptor (4)
TLR (4)
NOD (4)
Ras (4)
LTR (4)
FAK (3)
GPCR19 (3)
Cannabinoid Receptor (3)
PGE Synthase (3)
cholecystokinin (3)
CCR (3)
Somatostatin (3)
GST (3)
Adenosine deaminase (3)
Free radical scavengers (3)
TGF-beta/Smad (3)
IGF-1R (3)
AhR (3)
Arginase (3)
Akt (3)
Complement System (3)
Aminopeptidase (3)
Syk (3)
Aryl Hydrocarbon Receptor (3)
NOD-like Receptor (NLR) (3)
MT Receptor (3)
PAK (3)
Glutathione reductase (3)
c-Fms (3)
Glucokinase (3)
p38 MAPK (3)
Gap Junction Protein (3)
CXCR (3)
TOPK (2)
CGRP Receptor (2)
OAT (2)
IRE1 (2)
YAP (2)
CRM1 (2)
Sirtuin (2)
Integrase (2)
PLK (2)
ROR (2)
GlyT (2)
Na-K-Cl cotransporter (2)
Rho (2)
Thrombopoietin Receptor (2)
Monocarboxylate transporter (2)
Acyltransferase (2)
RSV (2)
MAPK (2)
Gamma-secretase (2)
LDL (2)
P2X Receptor (2)
Ephrin Receptor (2)
HIF (2)
Hexokinase (2)
GHSR (2)
GluCls (2)
CETP (2)
Isocitrate Dehydrogenase (IDH) (2)
Melanocortin Receptor (2)
Protease-activated Receptor (2)
PKM (1)
OX Receptor (1)
Histone Acetyltransferase (1)
NADPH-oxidase (1)
p53 (1)
PAD (1)
Lipase (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Epoxide Hydrolase (1)
ATP Citrate Lyase (1)
Phosphorylase (1)
PDK (1)
PD-1/PD-L1 (1)
IAP (1)
DUB (1)
VDA (1)
cAMP (1)
Telomerase (1)
Pyroptosis (1)
Dynamin (1)
Mdm2 (1)
MTH1 (1)
CSF-1R (1)
Epigenetic Reader Domain (1)
Chk (1)
Aurora Kinase (1)
Adiponectin receptor (1)
Hydrogenase (1)
Liver X Receptor (1)
S6 Kinase (1)
Platelet aggregation (1)
NPC1L1 (1)
PAFR (1)
IFNAR (1)
CRISPR/Cas9 (1)
Hck (1)
Nrf2 (1)
Na+/Ca2+ Exchanger (1)
Bradykinin Receptor (1)
Angiotensin-converting Enzyme (ACE) (1)
Taste receptor (1)
RAR/RXR  (1)
advanced glycation end products (1)
Beta-Secretase (1)
BACE (1)
GRK (1)
FAAH (1)
ACK (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE