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Stavudine
Catalog No. T1404Cas No. 3056-17-5
Alias Sanilvudine, NSC 163661, d4T, BMY-27857
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
Stavudine
Catalog No. T1404Alias Sanilvudine, NSC 163661, d4T, BMY-27857Cas No. 3056-17-5
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $33 | In Stock | |
| 100 mg | $47 | In Stock | |
| 200 mg | $65 | In Stock | |
| 500 mg | $97 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. |
| In vitro | In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT). |
| In vivo | Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM). |
| Alias | Sanilvudine, NSC 163661, d4T, BMY-27857 |
| Molecular Weight | 224.21 |
| Formula | C10H12N2O4 |
| Cas No. | 3056-17-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (223.01 mM)  H2O: 22.4 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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