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Naringin

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Purity:99.04%

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COA LCMS HPLC HNMR

Naringin

Catalog No. T0595Cas No. 10236-47-2

Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.

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Pack Size	Price	Availability
100 mg	$35	In Stock
200 mg	$48	In Stock
10 g	$68	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
In vivo	The Lethal Dose 50 for mice:1650 mg/kg.
Cell Research	HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].
Alias	Naringoside

Chemical Properties

Molecular Weight	580.53
Formula	C27H32O14
Cas No.	10236-47-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL (1.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (86.13 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.7226 mL	8.6128 mL	17.2256 mL	86.1282 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3445 mL	1.7226 mL	3.4451 mL	17.2256 mL
10 mM	0.1723 mL	0.8613 mL	1.7226 mL	8.6128 mL
20 mM	0.0861 mL	0.4306 mL	0.8613 mL	4.3064 mL
50 mM	0.0345 mL	0.1723 mL	0.3445 mL	1.7226 mL
100 mM	0.0172 mL	0.0861 mL	0.1723 mL	0.8613 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc