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Ingenol mebutate

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Purity:99.04%

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COA HPLC HNMR

Ingenol mebutate

Catalog No. TN1047Cas No. 75567-37-2

Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity.

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Pack Size	Price	Availability
1 mg	$64	In Stock
2 mg	$98	In Stock
5 mg	$209	In Stock
10 mg	$349	In Stock
25 mg	$577	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock

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Product Introduction

Bioactivity

Description	Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity.
In vitro	Ingenol mebutate shows EC50s for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-δ, PKC-ε and PKC-μ of 13, 4.37, 10.5, 38.6, 1.08 and 0.9 nM in WEHI-231 cells. The EC50s are 198, 69.1, 4.6, 1 nM in HOP-92 cells for PKC-α, PKC-βI, PKC-ε, PKC-μ and 635, 146, 4.7, 1.1, 30 nM for PKC-α, PKC-βI, PKC-δ, PKC-ε, PKC-μ in Colo-205 cells. Ingenol mebutate sensitizes WEHI-231 cells, HOP-92 and Colo-205 cells with IC50s of 1.41, 3.24, and 11.9 nM, respectively[2]. Ingenol mebutate (20 nM) induces apoptosis in a PKC-δ dependent manner in primary AML marrow blasts but not in normal myeloblasts[3].
Alias	Ingenol 3-Angelate, PEP005

Chemical Properties

Molecular Weight	430.53
Formula	C25H34O6
Cas No.	75567-37-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (209 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3227 mL	11.6136 mL	23.2272 mL	116.1359 mL
5 mM	0.4645 mL	2.3227 mL	4.6454 mL	23.2272 mL
10 mM	0.2323 mL	1.1614 mL	2.3227 mL	11.6136 mL
20 mM	0.1161 mL	0.5807 mL	1.1614 mL	5.8068 mL
50 mM	0.0465 mL	0.2323 mL	0.4645 mL	2.3227 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	1.1614 mL

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