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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Immunology/Inflammation related

Both the inflammatory response and the immune response are the body's defense mechanisms against various internal and external stimuli. The inflammatory response is often part of the immune response, which is usually acute and non-specific, whereas the immune response can be specific and may last longer after the infection has cleared. The inflammatory response functions primarily through local effects, while the immune response involves systemic regulation.

Filter HomeSignaling PathwaysImmunology/InflammationImmunology/Inflammation related

Tamarixetin

TN1039603-61-2

Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy.

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Cited

Galiximab

T76809357613-77-5

Galiximab (IDEC 114) is a primate-type anti-CD80 immunoglobulin G1 (IgG1)-like monoclonal antibody with antitumor activity that induces in vivo growth inhibition and prolongs survival of B-NHL tumor xenografts. Galiximab has been used in the study of hematologic malignancies.

$247

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Glycyrrhisoflavone

TN1705116709-70-7

Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.

$119

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Carotuximab

T769411268714-50-6

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.

$129

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Ac-YVAD-CMK

T36347178603-78-6

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

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N-trans-caffeoyltyramine

TN6457103188-48-3

N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.

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1,3,6-Tri-O-galloyl-beta-D-glucose

TN116618483-17-5

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

$118

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Pirazolac

T1248471002-09-0In house

Pirazolac (ZK-76604) is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.

$293

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INCB3619

T27603791826-72-7In house

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

$195

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Antalarmin hydrochloride

T22577220953-69-5

Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

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Omburtamab

T782741895083-75-6

Omburtamab is a monoclonal antibody targeting CD276, often conjugated to 131 radioactive iodine ions, used for radioimmuno positron emission tomography studies.

$213

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GI254023X

T7522260264-93-5

GI254023X is a MMP9 and ADAM10 inhibitor with IC50 values of 2.5 and 5.3 nM, respectively. GI254023X can also significantly inhibit the proliferation of Jurkat cells and induce apoptosis.

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Meranzin

TN101523971-42-8

Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1 2–BDNF signaling pathway. It offers promising potential for preventing the comorbidity of atherosclerosis and depression due to its significant anti-inflammatory and analgesic properties.

$106

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(+)-Isolariciresinol

TN1782548-29-8

(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis, exhibits antioxidant and anti-inflammatory activities, and is applicable in rheumatism studies.

$129

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Arnidiol

TN11116750-30-7

Arnidiol, a pentacyclic triterpene isolated from Barleria Longiflora Linn, exhibits anti-inflammatory activity, notably inhibiting 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

$122

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11-O-Galloylbergenin

T383282958-44-9

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

$193

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Ganoderic acid C2

TN1661103773-62-2

Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.

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Sericoside

T12466355306-04-2

Sericoside, a triterpenoid compound, is obtained from Terminalia and exhibits potent anti-inflammatory properties. Additionally, sericoside displays robust lipolytic activity, thereby aiding in the reduction of skin wrinkles and improvement of skin texture.

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Fendosal

T1996753597-27-6

Fendosal (HP-129) is a non-steroidal anti-inflammatory agent. It is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation.

$117

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JG26

T276541464910-32-4In house

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.

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Bryodulcosigenin

TN14554965-97-3

Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.

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Lintuzumab

T9901A-065166089-32-3

Lintuzumab (HuM-195) is a non-coupled humanized mouse monoclonal antibody directed against the cell-surface myelomonocyte differentiation antigen, CD33, with anti-leukemic activity that reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells.Lintuzumab has antitumor activity and induces cell death directly via CDC or ADCC. Lintuzumab has anti-tumor activity and induces cell death directly via CDC or ADCC.

$195

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Homobutein

TN422034000-39-0

Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

$195

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beta-Escin

T884611072-93-8

beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

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Handelin

TN113162687-22-3

Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.

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3-Epiursolic acid

TN1249989-30-0

3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the

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Tormentic acid

TN111813850-16-3

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

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Caulophyllogenin

TN147552936-64-8

Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the prevention and treatment of inflammatory diseases, type-2 diabetes, obesity and metabolic syndrome.

$113

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Eburicoic acid

TN1599560-66-7

Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer.

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Dehydropachymic acid

TN156377012-31-8

(S)-Leucic acid is an amino acid metabolite used as a muscle builder.

$113

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Izeltabart Tapatansine

T9901A-084

Izeltabart Tapatansine (IMGC-936) is a CHO-expressing humanized next-generation medetonin-based ADC compound targeting ADAM9-expressing tumors, and exhibits cytotoxicity against ADAM9-positive human tumor cell lines for cancer research.

$450

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Dehydrotumulosic acid

TN10856754-16-1

Dehydrotumulosic acid shows anti-inflammatory activity.

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ZLDI-8

T13410667880-38-8

ZLDI-8 is an inhibitor of Notch activating cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.

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Bucolome

T10632841-73-6

Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.

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TIM-3-IN-2

T793651113126-49-0

TIM-3-IN-2 is a Tim3 inhibitor that inhibits the binding of TIM-3 to PtdSer, CEACAM1, and Gal-9 and inhibits the action of TIM-3.TIM-3-IN-2 is able to reverse TIM-3-mediated pro-inflammatory cytokine action.

$149

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Glucosyringic acid

TN169733228-65-8

Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro.

$210

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Telazorlimab

T773692126777-87-3

Telazorlimab (GBR-830) is a humanized monoclonal antibody targeting the OX40 co-stimulatory receptor on activated T cells, and is used to treat lupus erythematosus and atopic dermatitis.

$247

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Acanthoside B

TN13557374-79-0

Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.

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Thymulin

TP232463958-90-7

Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune-modulatory and anti-inflammatory effects

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Kaempferol 3-O-β-D-galactopyranoside

TN182323627-87-4

Kaempferol 3-O-β-D-galactopyranoside possesses antioxidant, anti-inflammatory, and antinociceptive activities.

$128

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TL4-12

T262801620820-12-3

TL4-12 is a specific MAP4K2 GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM).

$106

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Myricetin 3-O-glucoside

TN196119833-12-6

Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) is a flavonol extracted from Tibouchina paratropica, exhibiting anti-leishmania, anti-inflammatory, and antibacterial activities.

$118

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Arjungenin

TN140258880-25-4

Arjungenin, a triterpene derived from Terminalia arjuna, exhibits insect feeding-deterrent and growth inhibitory properties.

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8-Epideoxyloganic acid

T383488668-99-9

8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit

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Fenclozic acid

T861417969-20-9

[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid (2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID) is an anti-inflammatory thiazole

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Adenosine N1-oxide

T23636146-92-9

Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.

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Heraclenin

TL00132880-49-1

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels

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