LAG-3

Lymphocyte activation gene 3 (LAG-3), also known as CD223, is a type I transmembrane protein that belongs to the immunoglobulin superfamily (IgSF). It is expressed on the surface of activated CD4+ and CD8+ T cells, regulatory T cells, Tr1 cells, natural killer (NK) cells, and plasmacytoid dendritic cells (pDCs) as dimers or oligomers. LAG-3 serves as a cell surface suppressor receptor that plays a crucial regulatory role in the immune system.