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Alkaloid Natural Product Library

Catalog No. L6110
  Library Compound List   Excel SDF

Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms, and mainly produced by plant. A large amount of research have found that alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. As research in alkaloids advances, alkaloids would play an important and visible role in modern drug development and provide a continuing source of novel drug leads.

TargetMol’s Alkaloid Natural Product Library carefully collects 317 alkaloids derived from plants, including Aconite, Periwinkle, Camptotheca acuminate, Belladonna, Coptis chinensis, etc. They have anticancer, anti-inflammatory, anti-oxidative, and neuroprotective effects. For example, vinca alkaloids obtained from Madagascar periwinkle plant are important for being cancer fighters and are the second-most-used class of cancer drugs and will stay among the original caner therapies. Lycorine, one of the main alkaloids of the Amaryllidaceae family, was found to be responsible for the pronounced antiviral and antibacterial activity of the crude extracts from the roots and leaves of Clivia miniata Regel. Tetrahydropalmatine, an isoquinoline alkaloid that is considered the active ingredient of Corydalis yanhusuo, has significant analgesic effects.

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Product Description

  • A unique collection of 317 natural alkaloids can be used for high throughput and high content screening;
  • Most compounds have confirmed bioactivity with anticancer, anti-inflammatory, anti-oxidative, and neuroprotective effects;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L6110)

Library Composition

AChR (30)
Topoisomerase (14)
5-HT Receptor (10)
Sodium Channel (9)
P450 (9)
Autophagy (8)
NF-κB (8)
Adrenergic Receptor (8)
Microtubule Associated (7)
Potassium Channel (7)
Antioxidant (6)
Antibacterial (6)
Antibiotic (5)
Dopamine Receptor (5)
Calcium Channel (4)
TRP/TRPV Channel (4)
p38 MAPK (4)
Antifection (4)
Antifungal (4)
Antiviral (3)
IDO (3)
GABA Receptor (3)
ERK (3)
Apoptosis (3)
PDE (3)
NOS (3)
Chloride channel (3)
Caspase (3)
Parasite (2)
Nucleoside Antimetabolite/Analog (2)
P-gp (2)
MAO (2)
IL Receptor (2)
AMPK (2)
PKC (2)
STAT (2)
Hedgehog/Smoothened (2)
ROS (2)
DNA/RNA Synthesis (2)
Prostaglandin Receptor (2)
BCL (2)
FAK (2)
Endogenous Metabolite (2)
EGFR (2)
TNF (2)
COX (2)
p53 (1)
Sirtuin (1)
TGF-beta/Smad (1)
S1P Receptor (1)
PARP (1)
PPAR (1)
PDGFR (1)
Proteasome (1)
TLR (1)
VEGFR (1)
Opioid Receptor (1)
DYRK (1)
Akt (1)
ATPase (1)
BACE (1)
Bcr-Abl (1)
Beta Amyloid (1)
CaMK (1)
Dehydrogenase (1)
DNA gyrase (1)
GluR (1)
NO Synthase (1)
HCV Protease (1)
HDAC (1)
HIF (1)
HSP (1)
MAPK (1)
MEK (1)
MMP (1)
MRP (1)
Histamine Receptor (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE