ReFRAME Related Library

Catalog No. L9230

Library Compound List Excel SDF

In 2018 Jeff Janes and his team constructed and published the ReFRAME library through data mining and literature research in the Proceedings of the National Academy of Sciences (PNAS). The team explained the application and utility of the ReFRAME library, where most of the compounds in the library have passed clinical trials Phase I with demonstrated safety profiles, which will significantly shorten the time to of drug candidates to enter clinical trials, reduce the risk of failure, and can be efficiently applied to early-stage drug development screening and discovery of lead compounds. The authors share the ReFRAME library on the Open Data Portal (https://reframedb.org ) with the aim of facilitating data sharing and drug discovery opportunities. The Global Center for Health Drug Development (GHDDI), founded by the Gates Foundation and Tsinghua University, has also applied the ReFRAME library to anti-COVID-19 drug discovery.

TargetMol has compiled a library of 3274 ReFRAME compounds, which is a useful tool for drug repurposing and anti-COVID-19 drug development.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 3274 compounds for high-throughput screening and high-content screening, an effective tool for drug repurposing and anti-COVID-19 drug development
Some compounds have been marketed and approved by FDA, EMA, NMPA and other authorities, and most have passed Phase I clinical studies
ReFRAME Related Library has excellent structural diversity through cluster analysis of structural diversity, including 2698 clusters (similarity between different clusters <70%), with an average of 1.2 compounds per cluster.
Covering multiple research areas: oncology, cardiovascular drugs, anti-inflammatory/immune, neurological drugs, respiratory drugs, etc.
Diverse targets, including 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc.
Detailed specifications, compound structure, target information, disease indication information, activity description, etc.
NMR, HPLC/LCMS and other detection techniques to ensure correct structure and high purity of the product and reduce false positives.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Autophagy (338)

Apoptosis (322)

Antibacterial (254)

Antibiotic (224)

Endogenous Metabolite (197)

5-HT Receptor (129)

COX (116)

Dopamine Receptor (96)

Parasite (92)

Adrenergic Receptor (90)

HIV Protease (78)

AChR (72)

DNA/RNA Synthesis (72)

Antifungal (68)

Histamine Receptor (66)

Calcium Channel (64)

PDE (61)

Potassium Channel (61)

PI3K (58)

VEGFR (57)

Sodium Channel (54)

P450 (50)

Estrogen/progestogen Receptor (46)

Reactive Oxygen Species (46)

GABA Receptor (46)

PPAR (45)

Glucocorticoid Receptor (44)

EGFR (42)

FLT (42)

Influenza Virus (42)

Prostaglandin Receptor (41)

Dehydrogenase (41)

HCV Protease (39)

Topoisomerase (39)

JAK (36)

CDK (35)

PDGFR (34)

Microtubule Associated (34)

Ferroptosis (33)

FGFR (32)

HDAC (32)

RAAS (31)

c-Met/HGFR (31)

SARS-CoV (30)

mTOR (30)

Src (29)

Adenosine Receptor (28)

Estrogen Receptor/ERR (28)

c-Kit (28)

iGluR (26)

NF-κB (26)

Mitophagy (25)

Androgen Receptor (25)

Virus Protease (24)

p38 MAPK (24)

Opioid Receptor (23)

Reverse Transcriptase (23)

MEK (22)

GPR (22)

Proteasome (22)

Progesterone Receptor (22)

Bcr-Abl (21)

GluR (21)

HBV (21)

HSV (21)

MAO (21)

HSP (20)

Nucleoside Antimetabolite/Analog (20)

TNF (20)

ROS (19)

Aurora Kinase (19)

TRP/TRPV Channel (19)

Tyrosine Kinases (18)

Akt (18)

PKC (17)

DNA Alkylator/Crosslinker (17)

ATPase (17)

Raf (17)

Retinoid Receptor (16)

Antifection (16)

Antioxidant (16)

Lipoxygenase (16)

NMDAR (16)

Carbonic Anhydrase (16)

HER (15)

AMPK (15)

CXCR (15)

Transferase (14)

Gamma-secretase (14)

MMP (14)

ALK (14)

CCR (13)

Cannabinoid Receptor (13)

Monoamine Oxidase (13)

Phospholipase (13)

Caspase (13)

ERK (13)

Epigenetic Reader Domain (13)

LPL Receptor (13)

E1/E2/E3 Enzyme (13)

Thyroid hormone receptor(THR) (13)

IL Receptor (13)

Beta Amyloid (13)

DNA-PK (12)

Mitochondrial Metabolism (12)

Thrombin (12)

TLR (12)

Histone Methyltransferase (12)

c-RET (12)

Nrf2 (12)

BTK (12)

DNA Alkylation (12)

DPP-4 (12)

PARP (12)

P-gp (12)

Endothelin Receptor (12)

STAT (11)

ribosome (11)

Integrin (11)

Drug Metabolite (11)

Vasopressin Receptor (11)

Trk receptor (11)

BCL (11)

PKA (11)

PLK (10)

TGF-beta/Smad (10)

CaMK (10)

Antiviral (10)

SGLT (10)

Reductase (10)

Phosphatase (10)

Interleukin (10)

TAM Receptor (10)

NO Synthase (10)

Acyltransferase (10)

Xanthine Oxidase (10)

Serotonin Transporter (10)

S1P Receptor (10)

CFTR (9)

Syk (9)

FXR (9)

Sigma receptor (9)

MRP (9)

ROCK (9)

HMG-CoA Reductase (9)

p53 (9)

Leukotriene Receptor (9)

Hedgehog/Smoothened (9)

Cysteine Protease (9)

Proton pump (9)

AChE (8)

Tyrosinase (8)

Serine Protease (8)

ATM/ATR (8)

GSK-3 (8)

c-Fms (8)

Glutathione Peroxidase (8)

IGF-1R (8)

IκB/IKK (7)

JNK (7)

LTR (7)

Glucokinase (7)

Neurokinin receptor (7)

Smo (7)

OX Receptor (7)

Aromatase (7)

DHFR (7)

Ras (7)

Serine/threonin kinase (7)

Mdm2 (7)

Norepinephrine (7)

Antifolate (7)

FAK (7)

HIF/HIF Prolyl-Hydroxylase (7)

Chk (7)

cholecystokinin (7)

Indoleamine 2,3-Dioxygenase (IDO) (7)

Guanylate cyclase (7)

LPA Receptor (6)

RSV (6)

Factor Xa (6)

NADPH (6)

Amino Acids and Derivatives (6)

CaSR (6)

Chloride channel (6)

Casein Kinase (6)

IAP (6)

CETP (6)

DNA gyrase (6)

Melatonin Receptor (5)

CSF-1R (5)

FAAH (5)

Hydroxylase (5)

Beta-Secretase (5)

S6 Kinase (5)

Wnt/beta-catenin (5)

Tie-2 (5)

ROS Kinase (5)

ABC (5)

Sirtuin (5)

DNA Methyltransferase (5)

IDO (5)

Aryl Hydrocarbon Receptor (4)

Fatty Acid Synthase (4)

Ephrin Receptor (4)

PGE Synthase (4)

BACE (4)

NOD-like Receptor (NLR) (4)

P2Y Receptor (4)

Acetyl-CoA Carboxylase (4)

PAK (4)

Platelet aggregation (4)

PAI-1 (4)

Glucosidase (4)

Annexin A (4)

Imidazoline Receptor (4)

Rho (4)

HIF (4)

Anti-infection (4)

ROR (4)

MT Receptor (4)

Monoamine Transporter (4)

Immunology/Inflammation related (4)

CAT (4)

Aminopeptidase (4)

UGT (4)

Kinesin (3)

Isocitrate Dehydrogenase (IDH) (3)

AhR (3)

Liver X Receptor (3)

PDK (3)

IFNAR (3)

CRFR (3)

transporter (3)

Hexokinase (3)

GNRH Receptor (3)

Complement System (3)

GlyT (3)

Neprilysin (3)

NAMPT (3)

Adenosine deaminase (3)

Na+/Ca2+ Exchanger (3)

NOD (3)

NOS (3)

Pim (3)

OAT (3)

Glutathione reductase (3)

Oxytocin Receptor (3)

Epoxide Hydrolase (3)

STING (3)

DUB (2)

Porcupine (2)

RIP kinase (2)

DprE1 (2)

Protease-activated Receptor (2)

SGK (2)

DNA (2)

advanced glycation end products (2)

ATP Citrate Lyase (2)

Discoidin Domain Receptor (DDR) (2)

c-Myc (2)

Histone Acetyltransferase (2)

CGRP Receptor (2)

CRISPR/Cas9 (2)

KSP (2)

CRM1 (2)

GPCR19 (2)

Lipid (2)

Thrombopoietin Receptor (2)

Melanocortin Receptor (2)

Telomerase (2)

Glucagon Receptor (2)

Monocarboxylate transporter (2)

GHSR (2)

Myosin (2)

Free radical scavengers (2)

Somatostatin (2)

FLAP (2)

Bradykinin Receptor (2)

Decarboxylase (2)

Stearoyl-CoA Desaturase (SCD) (2)

Galectin (2)

Gap Junction Protein (2)

Neuropeptide Y Receptor (2)

Na-K-Cl cotransporter (2)

Adenylyl cyclase (2)

Survivin (1)

Wee1 (1)

TOPK (1)

Thioredoxin (1)

VDA (1)

IRAK (1)

Pyroptosis (1)

GSNOR (1)

LDL (1)

KLF (1)

IRE1 (1)

Hydrogenase (1)

Histone Demethylase (1)

HCN Channel (1)

Hck (1)

GST (1)

GPX (1)

Lipase (1)

Glutaminase (1)

cell cycle arrest (1)

Carboxypeptidase (1)

cAMP (1)

BCRP (1)

ASK (1)

Anion Exchanger (1)

Angiotensin-converting Enzyme (ACE) (1)

LHRH (1)

lysosomal autophagy (1)

PYK2 (1)

p97 (1)

Protease (1)

Prolyl Endopeptidase (PREP) (1)

PKM (1)

PI4K (1)

PERK (1)

PD-1/PD-L1 (1)

PAFR (1)

PAD (1)

P2X Receptor (1)

MALT (1)

OXPHOS (1)

NPC1L1 (1)

NEDD8 (1)

NADPH-oxidase (1)

N-Acetylglucosaminyltransferase (1)

Motilin Receptor (1)

MNK (1)

Melanin-concentrating Hormone Receptor (MCHR) (1)

MAPK (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty