PROTAC Linker

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

TCO-NHS ester is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.

TAMRA-PEG3-Azide is a TAMRA red fluorescent dye linker with a maximum excitation emission wavelength of 553 575 nm.

Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker suitable for use in PROTAC synthesis.

Ac4GalNAz is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Biotin-PEG3-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

Biotin-PEG2-C2-iodoacetamide (Biotin-PEG2-iodoacetamide) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Biotin-PEG4-azide, a biotin-labeled, PEG-based PROTAC linker, is utilized in PROTAC synthesis.

m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.

DSPE-PEG-Biotin (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.

Squalane is a lipid found in some fish oils (especially shark liver oil) and some vegetable oils. It has anticancer and antioxidant properties and is used as a skin moisturizer and emollient.

m-PEG9-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs.

(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized ligand-linker for E3 ligase-based systems, comprising the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, commonly used in PROTAC technology.

Amino-PEG12-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Cbz-NH-PEG12-C2-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands to form PROTAC molecules, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.

m-PEG9-SH, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands and enables selective protein degradation through the ubiquitin-proteasome system within cells.

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker.

DBCO-S-S-PEG3-biotin is a cleavable reagent for the introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved with reducing agents such as DTT, BME, and TCEP to remove the biotin label. PEG linkers can also be used in the synthesis of PROTACs.

Azido-PEG4-azide is a PEG-based PROTAC linker used for synthesizing PROTACs.

5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.

Pomalidomide-PEG4-C2-NH2 hydrochloride is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl ether classes for the synthesis of a range of PROTAC molecules.

L-Azidohomoalanine hydrochloride (H-L-Aha-OH hydrochloride) is an alkyl chain-based PROTAC linker.

Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Azido-PEG1-amine is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.

DBCO-Biotin (Azadibenzocyclooctyne-Biotin conjugate) is a PROTAC linker based on the alkyl chain.

Azido-PEG2-C6-Cl is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azido-PEG9-azide is a PEG-based PROTAC linker suitable for use in PROTAC synthesis.

EGNHS (EGS crosslinker) is an alkyl ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and FGF21-receptor agonist, suitable for development as a potential treatment for T2DM.

m-PEG4-aldehyde is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker employed in PROTAC synthesis [1].

Biotin-PEG2-OH is a PEG-based PROTAC linker utilized in PROTAC synthesis.

Biotin-PEG6-azide (Biotin-PEG6-N3) is a biotin-labeled, PEG-based PROTAC linker that can be used in PROTAC synthesis.

Amino-PEG12-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-derived linker used for PROTAC synthesis.

PEG3-methylamine is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG24-acid (NH2-PEG24-COOH) is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.

Methyltetrazine-PEG5-NHS ester is a PROTAC linker belonging to the group of PEGs and is used for the synthesis of PROTAC molecules.