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Amino-PEG11-amine
Catalog No. T14226Cas No. 479200-82-3
Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment.
Amino-PEG11-amine
Catalog No. T14226Cas No. 479200-82-3
Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $30 | In Stock | |
| 50 mg | Inquiry | In Stock |
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1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.
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1,3-Dibromo-5,5-dimethylhydantoin
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Diethylene glycol bis(p-toluenesulfonate)
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T178237460-82-4
Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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Diethylene glycol bis(p-toluenesulfonate)
Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2
T178237460-82-4
Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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Diethylene glycol bis(p-toluenesulfonate)
Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2
T178237460-82-4
Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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Purity:95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment. |
| In vitro | PROTACs are bifunctional molecules consisting of two ligands linked together: one ligand targets an E3 ubiquitin ligase and the other targets the specific protein to be degraded. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1]. |
| Molecular Weight | 544.68 |
| Formula | C24H52N2O11 |
| Cas No. | 479200-82-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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