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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $30 | In Stock | |
50 mg | Inquiry | In Stock |
Description | Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment. |
In vitro | PROTACs are bifunctional molecules consisting of two ligands linked together: one ligand targets an E3 ubiquitin ligase and the other targets the specific protein to be degraded. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1]. |
Molecular Weight | 544.68 |
Formula | C24H52N2O11 |
Cas No. | 479200-82-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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