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ADC Linker

The linkers play a key role in ADC design as linkers link the cytotoxic drug to the mAb. Two primary linker types exist: non-cleavable and cleavable. Non-cleavable linkers are composed of stable bonds that resist proteolytic degradation, affording excellent stability in the systemic circulation.

Fmoc-PEA
T17977329223-23-6In house
Fmoc-PEA (Example 1-2) is utilized as a cleavable linker for antibody-drug conjugates (ADC).
  • $43
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DOTA-​NHS-​ester
T17842170908-81-3
DOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection.
  • $41
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N3-C3-NHS ester
T18466943858-70-6
N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • $50
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DSG Crosslinker
T1517179642-50-5
DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $39
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DTSSP Crosslinker
T1517981069-02-5
DTSSP Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $37
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Mc-Val-Cit-PAB-Cl
T183211639351-92-0
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
  • $119
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SPDB
T4346115088-06-7
SPDB is a degradable ADC linker that can be used to synthesize antibody-drug conjugates. SPDB is a small fragment attached to the DM4 conjugate and conjugated to the antibody using a disulfide bond.
  • $30
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SMCC
T911664987-85-5
SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.
  • $30
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Sulfo-SMCC sodium
T1872892921-24-9
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
  • $41
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BS3 Crosslinker disodium
T14833L127634-19-9
BS3 Crosslinker disodium, a non-cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).
  • $41
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DBCO-NHS ester
T150671353016-71-3
DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).
  • $31
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Mal-amide-PEG8-Val-Ala-PAB-PNP
T778682210247-59-7
Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable linker used in the production of antibody-drug conjugates (ADCs), enabling the attachment of cytotoxic drugs to antibodies for targeted delivery [1].
  • $98
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TCO-PEG4-NHS ester
T170171613439-69-2
TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $61
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DSS Crosslinker
T1517668528-80-3
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.
  • $41
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m-PEG8-Ms
T159351059588-19-0
m-PEG8-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
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Aminooxy-PEG3-azide
T142641306615-51-9
Aminooxy-PEG3-azide is an ADC linker belonging to the class of PEGs, as well as three-unit PEGs, which can be used for the synthesis of antibody-coupled reactive molecules (ADCs).
  • $37
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Gly-Gly-Gly-PEG4-DBCO
T179872353409-80-8
Gly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
  • $84
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DBCO-amine
T150581255942-06-3
DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
  • $32
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MFCD28987368
T89241610413-97-2
MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).
  • $50
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Propargyl-C1-NHS ester
T18560132178-37-1
Propargyl-C1-NHS ester (4-Pentynoic Acid Succinimidyl Ester) is a nonclaevable linker used for antibody-drug-conjugation (ADC).
  • $30
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DSP Crosslinker
T1517557757-57-0
DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].
  • $30
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N3-C5-NHS ester
T18468866363-70-4
N3-C5-NHS ester, a noncleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
  • $53
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N3-PEG4-C2-NHS ester
T16259944251-24-5
N3-PEG4-C2-NHS ester is a noncleavable, four-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs).
  • $35
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MC-Gly-Gly-Phe
T183081599440-15-9
MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).
  • $29
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SPDP
T674168181-17-9
SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11
  • $16
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MC-Gly-Gly-Phe-Gly
T86672413428-36-9
MC-Gly-Gly-Phe-Gly (DSN28369) is a heterobifunctional linker, and useful to make antibody drug conjuate (ADC).
  • $30
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m-PEG8-NHS ester
T15936756525-90-3
m-PEG8-NHS ester is an 8-unit PEG-containing ADC linker that can be used to synthesize antibody-coupled reactive molecules (ADCs), which can be used to modify proteins and peptides.
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N-Hydroxysulfosuccinimide sodium
T16225106627-54-7
N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
  • $45
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Tetrazine-PEG4-SS-NHS
T18791
Tetrazine-PEG4-SS-NHS is a degradable ADC linker containing 4 units of PEG that can be used to synthesize antibody-coupled reactive molecules (ADCs).
  • $120
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N-Butanoyl-L-homoserine lactone
T1840867605-85-0
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
  • $29
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Mal-PEG4-NHS ester
T159911325208-25-0
Mal-PEG4-NHS ester is a noncleavable ADC linker with a Maleimide group, a 4-unit PEG, and an NHS ester.
  • $36
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SPDMV
T18707890409-85-5
SPDMV is a PEG-based ADC linker involved in the synthesis of antibody-coupled reactive molecules (ADCs).
  • $35
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6-Azido-hexylamine
T40434349553-73-7
6-Azido-hexylamine is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $30
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Aloe vera
T800185507-69-3
Aloe vera has anti-inflammatory, antimicrobial, antioxidant and wound healing properties and can be used to study skin damage and GERD.
  • $37
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BOC-Dap-NE
T22278160800-65-7
Boc-Dap-NE used in the synthesis of antibody-drug conjugates (ADCs).It is a cleavable ADC linker
  • $30
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FMoc-Val-Cit-PAB-PNP
T7767863971-53-3
Fmoc-Val-Cit-PAB-PNP is a linker used in Antibody-Drug Conjugation (ADC).
  • $116
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Succinic anhydride
T18723108-30-5
Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
  • $29
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Fmoc-Val-Ala-PAB-OH
T42861394238-91-5
Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.
  • $40
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N3-C2-NHS ester
T18465850180-76-6
N3-C2-NHS ester (3-Azidopropanoic acid NHS ester) is an ADC linker, which is a cross-linking agent for macromolecular compounds, and can be used for the synthesis of antibody-coupled reactive molecules (ADCs).
  • $32
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MC-Val-Cit-PABC-PNP
T3503159857-81-5
MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.
  • $29
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BS3 Crosslinker
T1483382436-77-9
BS3 Crosslinker is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. It connects antibodies with drugs, thereby enhancing the overall efficiency and effectiveness of the resulting ADC.
  • $30
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Fmoc-Gly-Gly-OH
T1795235665-38-4
Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
  • $30
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Boc-Val-Cit-PAB-PNP
T17692870487-10-8
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-NH-PEG8-CH2CH2COOH
T15322756526-02-0
Fmoc-NH-PEG8-CH2CH2COOH is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) for forming antibody-drug conjugates [1].
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Fmoc-Lys-OH hydrochloride
T41312139262-23-0
Fmoc-Lys-OH hydrochloride is an alkyl-chain-based PROTAC linker and a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $29
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NH-bis(C1-Boc)
T1847985916-13-8
NH-bis(C1-Boc) is an uncleavable linker used for antibody-drug conjugates (ADC).
  • $37
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N3-C4-NHS ester
T18467478801-48-8
N3-C4-NHS ester, a non-cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
  • $48
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Boc-Gly-Gly-Phe-Gly-OH acetate
TP1159L
Boc-Gly-Gly-Phe-Gly-OH acetate (GGFG acetate) is a self-assembly of N- and C-protected tetrapeptide.
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