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Hydroxy-PEG10-acid
🥰Excellent
Catalog No. T18031Cas No. 2375611-66-6
Alias HO-PEG10-CH2CH2COOH
Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].
Hydroxy-PEG10-acid
🥰Excellent
Catalog No. T18031Alias HO-PEG10-CH2CH2COOHCas No. 2375611-66-6
Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 27 € | In Stock | |
| 10 mg | 37 € | In Stock | |
| 25 mg | 55 € | In Stock | |
| 50 mg | 81 € | In Stock | |
| 100 mg | 110 € | In Stock |
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Succinic anhydride
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Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
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6-Maleimidocapronic acid
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6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).
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11-Aminoundecanoic acid
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11-Aminoundecanoic acid, an alkyl chain-based PROTAC linker, is employed in PROTAC synthesis.
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1,3-Dibromo-5,5-dimethylhydantoin
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1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.
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Diethylene glycol bis(p-toluenesulfonate)
Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2
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Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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Fmoc-8-amino-3,6-dioxaoctanoic acid
Fmoc-NH-PEG2-CH2COOH
T15304166108-71-0
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
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1-Bromo-6-chlorohexane
Hexane, 1-bromo-6-chloro-, 6-Chlorohexyl bromide, 6-Bromohexyl Chloride, 1-Chloro-6-bromohexane
T407286294-17-3
1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.
- 33 €
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Pentaethylene glycol
3,6,9,12-Tetraoxatetradecane-1,14-diol
T164684792-15-8
Pentaethylene glycol (3,6,9,12-Tetraoxatetradecane-1,14-diol) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
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Bis-Tos-PEG4
Tetraethylene glycol di(p-toluenesulfonate), PROTAC Linker 16, 1,11-Bis(tosyloxy)-3,6,9-trioxaundecane
T1861437860-51-8
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based linker utilized in the synthesis of PROTACs.
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Decaethylene glycol
HO-PEG10-OH
T150895579-66-8
Decaethylene glycol (HO-PEG10-OH) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
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DSG Crosslinker
T1517179642-50-5
DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-Gly-Gly-OH
T1795235665-38-4
Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1]. |
| In vitro | PROTACs, consisting of two ligands connected by a linker—one targeting an E3 ubiquitin ligase and the other the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Alias | HO-PEG10-CH2CH2COOH |
| Molecular Weight | 530.6 |
| Formula | C23H46O13 |
| Cas No. | 2375611-66-6 |
| Smiles | C(OCCOCCOCCOCCOCCOCCOCCO)COCCOCCOCCC(O)=O |
| Relative Density. | 1.143 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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