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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1]. |
In vitro | ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker[1]. PROTACs feature two ligands connected by a linker; one targets an E3 ubiquitin ligase, the other targets the protein of interest. PROTACs utilize the intracellular ubiquitin-proteasome system for selective protein degradation[1]. |
Alias | tris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamine |
Molecular Weight | 505.64 |
Formula | C25H47NO9 |
Cas No. | 175724-30-8 |
Relative Density. | 1.065 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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